超顺磁性Fe_3O_4纳米粒子在磁共振造影中的应用

Applications of Superparamagnetic Fe_3O_4 Nanoparticles in Magnetic Resonance Imaging

超顺磁性Fe3O4纳米粒子由于其廉价、低毒及超顺磁等特性,已成为重要的一类磁共振造影剂。本文综述了超顺磁性Fe3O4纳米粒子的可控制备方法,归纳总结影响粒径、结晶度和磁性能的主要因素和影响规律;为进一步提高磁性能并实现多功能,总结了Fe3O4纳米粒子进一步组装和表面改性的方法和机理;系统讨论了Fe3O4纳米粒子的形貌、尺寸和表面性能等对磁性能和生物相容性的影响规律;并指出了Fe3O4纳米粒子在磁共振造影领域潜在的发展方向和研究热点。

Fe304nanomaterials have attracted tremendous attention in the helo ot magneuc resonance imaging （MRI） because of their low cost, good biocompatibility, favorable superparamagnetic properties. This article focuses on the controlled preparation methods of superparamagnetic Fe304nanoparticles, and provides an in-depth discussion of the key factors and their influence rules for particle size, crystallinity and magnetic properties. The current status of available methodologies and mechanisms for the assembly and surface modification of Fe304 nanoparticles are highlighted to generate high performance and multifunction. We also systematically summarize the effect of particle size, morphology and surface properties on the magnetic and toxic properties of Fe304 nanoparticles. Finally, the future opportunities and challenges of Fe3O4 nanomaterials used as MRI contrast agents are addressed to our understanding.