Natural products from Bacillus subtilis with antimicrobial properties

枯草芽孢杆菌产天然产物及其抗菌性（英文）

Bacillus subtilis produces many chemlcally-dwerse seconaary metaDolltes or interest to chemists ano biologlsts. Based on this, this review gives a detailed overview of the natural components produced by B. subtilis including cyclic lipopeptides, polypeptides, proteins （enzymes）, and non-peptide products. Their structures, bioactive ac- tivities and the relevant variants as novel lead structures for drug discovery are also described. The challenging effects of fermentation metabolites, isolation and purification, as well as the overproduction of bioactive com- pounds from B. subtilis by metabolic engineering, ＇~ere also highlighted. Systematically exploring biosynthetic routes and the functions of secondary metabolites from 13. subtilis may not only be beneficial in improving yields of the products, but also in helping them to be used in food industry and public medical service on a large-scale.

Bacillus subtilis produces many chemically-diverse secondary metabolites of interest to chemists and biologists.Based on this,this review gives a detailed overview of the natural components produced by B.subtilis including cyclic lipopeptides,polypeptides,proteins(enzymes),and non-peptide products.Their structures,bioactive activities and the relevant variants as novel lead structures for drug discovery are also described.The challenging effects of fermentation metabolites,isolation and purification,as well as the overproduction of bioactive compounds from B.subtilis by metabolic engineering,were also highlighted.Systematically exploring biosynthetic routes and the functions of secondary metabolites from B.subtilis may not only be beneficial in improving yields of the products,but also in helping them to be used in food industry and public medical service on a large-scale.