卡介菌多糖核酸联合5%米诺地尔酊治疗斑秃的临床疗效观察

The clinical efficacy of minoxidil and BCG-polysaccharide nucleic acid in the treatment of alopecia areata

目的:观察卡介菌多糖核酸联合5%米诺地尔酊治疗斑秃的临床疗效和安全性。方法:将80例斑秃患者随机分成两组。试验组:40例,采用卡介菌多糖核酸联合5%米诺地尔酊治疗;对照组:40例,仅外用5%米诺地尔酊治疗。两组治疗12周后评价疗效及不良反应。结果:治疗12周后,试验组有效率为79.5%,高于对照组的57.9%,两组间差异有统计学意义(P<0.05),两组间不良反应发生率比较无显著性差异。结论:卡介菌多糖核酸注射液与5%米诺地尔酊联合使用治疗斑秃,可发挥协同治疗作用,安全性好。

Objective To observe the clinical efficacy and safety of minoxidil with BCG-polysaccharide nucleic acid in the treatment of alopecia areata. Methods 80 patients with alopecia areata were randomly divided into two groups：the experimental group was treated with minoxidil and BCG-polysaccharide nucleic acid,while the control group was treated with minoxidil only. The efficacy and side effects was evaluated after treated 12-week treatment. Results After 12 weeks treatment,the total effective rates were 79.5%in the experiment group and 57.9%in the control group （P〈0.05）.There were no significant difference in side effective rate between two groups. Conclusion It is effective and safe for minoxidil in combination with BCG-polysaccharide nucleic acid in the treatment of alopecia areata.