奥昔康唑联合特比萘芬治疗甲真菌病疗效观察

Observation of the curative effect of Oxiconazole combined with Terbinafine for the treatment of onychomycosis

目的:观察奥昔康唑联合特比萘芬治疗甲真菌病的疗效。方法:选取2012年7月-2014年8月就诊的患有甲真菌病的90例患者,随机分为A、B、C三组,每组30例。A组:采用硝酸奥昔康唑乳膏外涂,每天2次,连用12周;B组采用盐酸特比萘芬片口服,0.25g/d,连用12周;C组采用硝酸奥昔康唑乳膏外涂,每天2次,同时口服盐酸特比萘芬片,0.25g/d,两种药物连用12周。依据SCIO评分,观察治疗全程中的疗效及不良反应。结果:连用12周后,A组总有效率70.0%,B组66.7%,C组90.0%,C组总有效率明显高于A、B两组,具有统计学意义(P<0.05)。不良反应中,A组外用硝酸奥昔康唑软膏时有3例患者先后发生瘙痒、轻度烧灼感;B组口服盐酸特比萘芬片过程中有4例患者先后出现胃肠道反应、皮疹;C组联合用药,有4例患者先后发生瘙痒、轻度烧灼感,有6例患者先后出现胃肠道反应、皮疹。三组患者不良反应均为轻微或一过性反应,无统计学意义(P>0.05)。结论:硝酸奥昔康唑乳膏联合盐酸特比萘芬片治疗甲真菌病比单一用药疗效更为肯定,可临床推广应用。

Objective Observation of the curative effect of Oxiconazole combined with Terbinafine for the treatment of onychomycosis. Methods 90 patients with onychomycosis were randomly divided into 3 groups,each group consisted of 30 patients.Group A was treated Oxiconazole Cream,two times a day for 12 weeks.Group B took Terbinafine Tablets,0.25g/d for 12 weeks. Group C was treated by topical and oral simultaneously.According to SCIO score, observed the curative effect and adverse reaction in the treatment. Results A group’s total efficiency was 70.0% after 12 weeks,B was 66.7%, and C was 90.0%.There were significant differences between A and B,C（P〈0.05）.The adverse reaction,Group A had 3 cases occurred itching,mild burning sensation.Group B had 4 patients appeared gastrointestinal reaction, rash. In Group C,4 cases had occurred itching,mild burning sensation,6 cases had appeared gastrointestinal reaction, rash. There was no statistical significance between the three groups（P〉0.05）. Conclusion It has more effective to treat onychomycosis with Oxiconazole combined with Terbinafine.