点阵激光辅助局部用药的研究进展

Fractional laser-assisted topical drug delivery

在皮肤科治疗中,局部用药应用广泛,如何提高传统局部经皮给药的生物利用度具有重要的应用价值.近年来研究发现,激光可以促进药物透过皮肤,不仅提高药物吸收率,也增加其渗透深度.传统剥脱激光作用效果显著,但其不良反应如红斑、疼痛等发生率较高.点阵激光的出现,突破传统激光的局限,其局灶性光热作用的原理,提高药物透皮作用的同时降低光热损伤,显示出较强的临床应用优势.

Topical drugs have been widely applied to the treatment of dermatoses,and improving the bioavailability of drugs delivered via traditional transdermal routes is of great value.Recent studies have found that lasers can promote drugs to penetrate the skin with an increase in drug absorbility and penetration depth.Although traditional ablative lasers have remarkable therapeutic effect,there is a high incidence of adverse reactions such as erythema and pain.Based on the theory of selective photothermolysis,fractional lasers can improve skin permeability of drugs with reduced photothermal damage,have broken through the limitations of traditional lasers and shown great potential in clinical application.