梅毒螺旋体部分膜蛋白研究进展

Progress in some membrane proteins of Treponema pallidum

梅毒是由梅毒苍白螺旋体引起的一种可侵犯多器官的慢性性传播疾病.目前梅毒螺旋体尚不能在体外长期培养,获取较困难,从而阻碍了对梅毒致病机制的研究、诊疗方案的优化和疫苗的研制.梅毒螺旋体全基因序列的揭示,TprK蛋白、Tp0483蛋白、Tp0155蛋白等一些重要膜蛋白成功表达及对其结构特点、抗原性和免疫保护作用的深入研究,为梅毒发病机制的研究、诊疗方案的优化和疫苗的研制提供了基础和可能.概述近年来新发现的对梅毒螺旋体具有诊断意义和免疫保护作用的几种主要膜蛋白的研究状况.

Syphilis,a chronic sexually transmitted disease caused by Treponema pallidum （Tp）,can affect multiple organs.At present,Tp can not been cultured in vitro for a long time and is difficult to obtain,which has hampered the exploration into the pathogenesis of syphilis,optimization of syphilis diagnosis and treatment,and development of syphilis vaccines.The identification of complete genome sequence of Tp,successful expressions of some important membrane proteins such as TprK,Tp0483 and Tp0155,and in-depth study of the structural characteristics,antigenicity and immunoprotective effect of these membrane proteins have provided the basis for and possibility of investigating into the pathogenesis of,optimizing the diagnosis and treatment of,and developing vaccines for,syphilis.The authors summarize recent advances in some major membrane proteins of Tp with diagnostic value and immunoprotective effect.