sclerostin在骨代谢中的作用和机制

Effects and mechanisms of sclerostin in bone metabolism

sclerostin是由SOST编码的糖蛋白,可以通过与Lrp4/5/6受体结合抑制Wnt信号通路,发挥调节骨代谢的作用。硬化性骨病、Van Buchem病、颅骨骨干发育异常等染色体异常性疾病及骨质疏松症均与SOST基因突变有关。近年来研究证实sclerostin不仅可以通过多种途径阻碍成骨细胞分化而发挥抑制骨形成的作用,还可以通过促进破骨细胞生成和依赖RANKL的方式激活破骨细胞功能促进骨吸收。sclerostin单克隆抗体为骨质疏松症的治疗提供了新的途径,目前正在进行临床试验,其有效性及安全性需要进一步研究。

Sclerostin is a glycoprotein encoding by SO STgene and can bind to Lrp4 /5 /6 receptor to block the W nt signaling pathway, so as to regulate the bone metabolism.M utations of the SO STgene are relevant to osterporosis and autosomal dominant diseases such as sclerosteosis, V an Buchemdisease, and craniodiaphyseal dysplasia.Recent studies have confirmed that sclerostin can not only block the differentiation of osteoblast to inhibit bone formation by various ways, but also have a catabolic action through promotion of osteoclast formation and activation of osteocytes in a RAN KL-dependent manner.The sclerostin monoclonal antibody may bring a newway for the treatment of osteoporosis.Currently, the clinical test is underway.The safety and validity of sclerostin monoclonal antibody need to be further researched.