摘要
目的:通过测量广州地区正常汉族人群的股骨颈上部区域骨密度( bone mineral density, BMD),确定本地区股骨颈上部区域骨密度的正常参考值,并探讨其随年龄变化的规律。方法使用美国Lunar公司生产的DPX型双能X线骨密度仪( dual-energy x-ray absorptiometer,DXA)对广州地区20岁以上汉族健康人1342例(男648人,女694人)双侧股骨近端BMD进行测定。按不同性别29岁及以下、70岁及以上各为一个年龄组,30~69岁每5岁分为一年龄组,得出骨密度均值、标准差及累计丢失百分率。结果①广州地区男、女性双侧股骨上部1/2区域骨密度峰值( peak bone density,PBD)均出现在20~29岁年龄组;此后,随年龄增长BMD降低,女性BMD在45岁后加速下降,男性无加速下降倾向。②广州地区双侧股骨颈中段上部1/2区域骨质疏松症的诊断参考值:男性为0.627 g/cm2,女性为0.487 g/cm2。结论股骨上部1/2区域是检测骨质疏松的敏感部位,其BMD测量值具有良好的年龄相关性,且女性骨质丢失增速出现年龄更早。
Objective By measuring bone mineral density ( BMD ) at the upper part of the femoral neck among the Han nationality in Guangzhou area, to determine the reference value of BMD in normal people in this area, and to investigate the BMD change according to age.Methods BMD of proximal femurs was measured using DEXA ( Lunar, US) in 1342 healthy people of the Han nationality who were more than 20 years old (648 males and 694 females).Patients were divided into groups according gender and age.Those who were below 29 or over 70 were in separate groups.Those who were between 30 and 69 years-old were in groups with a 5-year interval.The mean and standard deviation of BMD and accumulate bone lose were calculated.Results 1) The peak bone density (PBD) of the upper part of the femoral neck was in the group whose age was between 20 and 29 years old in both males and females.Afterwards, BMD decreased with the increasing of age.BMD decreased rapidly in the female whose age was more than 45, but the tendency of rapid decrease in BMD was not in males at the same age.2) The reference values of BMD for osteoporosis diagnosis at the upper part of the femoral neck were 0.627g/cm2 in males and 0.487 g/cm2 in females in the Han nationality in Guangzhou area.Conclusion Measuring BMD at the upper part of the femoral neck is a sensitive method to diagnose osteoporosis.The measured value has better correlation with age.The appearance of bone loss occurs earlier in females.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2015年第4期472-475,共4页
Chinese Journal of Osteoporosis
关键词
股骨颈上部区域
骨密度
骨质疏松症
正常人群
Upper part of the femoral neck
Bone mineral density
Osteoporosis
Normal people