期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

树突状细胞疫苗治疗恶性肿瘤研究进展 被引量：4

Research progress of dendritic cell vaccination for malignant tumors therapy
原文传递
导出
摘要 随着对树突状细胞生物学特性认识的不断深入,有关树突状细胞的培养、激活、抗原加载、基因修饰以及树突状细胞疫苗治疗恶性肿瘤的研究均取得了较大进展。本文就近年来树突状细胞疫苗治疗恶性肿瘤的现状与研究进展作一综述。 With the deep understanding of biological characters of dendritic cell, much progress has been gained in culture, activation, antigen pulsing and genetic modification of dendritic cell. Dendritic cell vaccination for malignant tumors immunotherapy has achieved an encouraging result. This paper reviews the development of dendritic cell vaccination for malignant tumors in recent years.
作者 冯鹏飞 韩双印
机构地区 郑州大学人民医院 河南省人民医院消化内科
出处 《中华实用诊断与治疗杂志》 2015年第5期420-422,共3页 Journal of Chinese Practical Diagnosis and Therapy
基金 国家自然科学基金(81372405) 国家卫计委基金项目(201301010)
关键词 恶性肿瘤 树突状细胞 免疫治疗 Malignant tumors dendritic cells immunotherapy
分类号 R730.51 [医药卫生—肿瘤]
  • 相关文献

参考文献22

  • 1Anguille S, Smits EL, Lion E, et al. Clinical use of dendritic cells for cancer therapy[J]. Lancet Oncol, 2014, 15 (7) : e257- 267.
  • 2Hsu FJ, Benike C, Fagnoni F, et al. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells[J]. Nat Med,1996,2(1):52-58.
  • 3Sehadendorf D, Ugurel S, Schuler-Thurner B, et al. Dacarbazine (DTIC) versus vaccination with autologous peptide- pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase Ⅲ trial of the DC study group of the DeCOG[J]. Ann Oncol, 2006, 17 (4) : 563- 570.
  • 4Fadul CE, Fisher JL, Hampton TH, etal. Immune response in patients with newly diagnosed glioblastoma multiforme treated with intranodal autologous tumor lysate-dendritic cell vaccination after radiation chemotherapy[J]. J Immunother, 2011,34 (4) 382- 389.
  • 5Shore ND, Mantz CA, Dosoretz DE, et al. Building on sipuleucel-T for immunologic treatment of castration-resistant prostate cancer[J]. Cancer Control,2013,20(1) :7-16.
  • 6Harris KM. Monocytes differentiated with GM-CSF and IL-15 initiate Th17 and Thl responses that are contact-dependent and mediated by IL 15[J]. J LeukocBiol,2011,90(4):727-734.
  • 7Trepiakas R, Pedersen AE, Met O, et al. Addition of interferon-alpha to a standard maturation cocktail induces CD38 up-regulation and increases dendritic cell function[J]. Vaccine, 2009,27(16):2213-2219.
  • 8Navabi H, Jasani B, Reece A, et al. A clinical grade poly I:C- analogue (Ampligen) promotes optimal DC maturation and Thl- type T cell responses of healthy donors and cancer patients in vitro[J]. Vaccine,2009,27(1) :107 115.
  • 9杨麦贵,杨阳,岳波,郭树忠,庄然,张小宁,郝晓柯.细胞因子诱导的imDCs鉴定及免疫学功能研究[J].中华实用诊断与治疗杂志,2011,25(5):466-469. 被引量：3
  • 10Erdmann M, D6rrie J, Schaft N, et al. Effective clinical-scale production of dendritic cell vaccines by monocyte elutriation directly in medium, subsequent culture in bags and final antigen loading using peptides or RNA transfection[J]. J Immunother, 2007,30(6) : 663-674.

二级参考文献33

  • 1湛海伦,高新,邱剑光,蔡育彬,司徒杰,温星桥.抗原致敏DC与CIK共培养体外抗肾癌效应的研究[J].中国病理生理杂志,2006,22(10):1993-1996. 被引量：9
  • 2尹路,陈春球,陈桂明,周光文,周慧江,施敏敏,李宏为.大鼠小肠系膜淋巴组织抗原刺激同种异体混合淋巴细胞增殖反应研究[J].中华外科杂志,2007,45(9):626-629. 被引量：4
  • 3Wolfers J, Lozier A, Raposo G, et al. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross- priming[J]. Nat Med,2001,7(3):297 -303.
  • 4Hsu D H, Paz P, Villaflor G, et al. Exosomes as a tumor vaccine:enhancing potency through direct loading of antigenic peptides[J]. J Immunother,2003,26(5):440- 450.
  • 5Andre F, Chaput N, Schartz N E, et al. Exosomes as potent cellfree peptide-based vaccine. I. Dendritic cell-derived exosomes transfer functional MHC class I/peptide complexes to dendritic cells[J]. J Immunol,2004,172(4):2126 -2136.
  • 6Lamparski H G, Metha-Damani A, Yao J Y, et al. Production and characterization of clinical grade exosomes derived from dendritic cells[J]. J Immunol Methods,2002,270(2):211 -226.
  • 7Viaud S, Terme M, Flament C, et al. Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role forNKG2D ligandsand IL-15 Ralpha[J]. PlosOne,2009, 4(3) :e4942.
  • 8Kim T G, Kim C H, Won E H, et al. CpG-ODN stimulated dendritic ceils act as a potent adjuvant for E7 protein delivery to induce antigen specific antitumour immunity in a HPV 16 E7 associated animal tumonr model[J]. Immunology, 2004,112 ( 1 ) : 117-125.
  • 9Clayton A, Mason M D. Exosomes in tumour immunity[J]. Curr Oncol,2009,16(3) :46- 49.
  • 10Bianco N R, Kim S H, Morelli A E, et al. Modulation of the immune response using dendritic cell-drived exosomes [J]. Methods Mol Biol,2007(380) :443-455.

共引文献9

同被引文献33

引证文献4

二级引证文献5

中华实用诊断与治疗杂志
2015年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部