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腹主动脉瘤动物模型的选择 被引量：2

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摘要 腹主动脉瘤（AAA）病情凶险,是60岁以上男性的第10位死因,美国每年AAA破裂导致的死亡人数为15 000例[1].已知的危险因素有男性、吸烟、高龄、遗传倾向、脂代谢异常和高血压.AAA的组织学表现为中膜和外膜大量炎性细胞浸润,弹力纤维断裂及中膜降解,但病因不明.选择安全可靠、可重复的动物模型对于理解AAA的发生机制具有重要作用,也为新型药物和手术方式提供参考价值.
作者 胡国华 符伟国
机构地区 复旦大学附属中山医院复旦大学血管外科研究所
出处 《中华医学杂志》 CAS CSCD 北大核心 2015年第16期1272-1274,共3页 National Medical Journal of China
基金 国家自然科学基金（81270387）
关键词 腹主动脉瘤动物模型 炎性细胞浸润 组织学表现 脂代谢异常 死亡人数 危险因素 遗传倾向 弹力纤维
分类号 R543.1 [医药卫生—心血管疾病] R-332 [医药卫生]
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参考文献38

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中华医学杂志
2015年 第16期

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