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T淋巴细胞上主要离子通道的生理学和药理学研究进展 被引量:2

The physiological and pharmacological study of major ion channels in T lymphocytes
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摘要 T淋巴细胞是生物体内最重要的免疫细胞之一,在机体免疫系统中发挥着重要作用。它的活化、增殖离不开膜上的离子通道。T淋巴细胞膜上有5种离子通道与它的活性关系密切,它们作为免疫调节过程的潜在靶点发挥重要作用。Ca2+通过Ca2+通道(Ca2+-release activated Ca2+channels,CRAC channels)进入T淋巴细胞作为第二信使参与T淋巴细胞的激活;K+离子通道参与T淋巴细胞的膜电位调节,同时它与Cl-通道(Clswell)共同参与T淋巴细胞的体积调节;TRPM7(transient receptor potential melastatin7)维持T淋巴细胞内Mg2+的平衡。本文扼要回顾了5种离子通道的研究进展,选择性的描述电压门控钾离子通道(KV1.3)以及钙离子依赖型钾离子通道(KCa3.1)离子通道阻滞剂研究进展与药理学意义。 T lymphocyte is an important immunocyte, which plays an important role in cellular and humoral immunity. Research has demonstrated that ion channels were vital for T lymphocyte activation and proliferation. There are five distinct types of ion channels comprising a network that performs functions vital for ongoing cellular homeostasis and for T-cell activation. Ca2+ influx through Ca2+-release activating Ca2+ (CRAC) is essential to trigger T lymphocyte activation; K+ channels contribute to the formation of T lymphocyte membrane potential; Cl- channel (Clswell) and KV1.3 work together functionally in T lymphocyte in the regulation of cellular volume; TRPM7 play a role in Mg2+ homeostasis. Here we review the recent progress on the five ion channels in T lymphocyte and the blockers of the ion channels-voltage gated potassium channel (KV1.3) and calcium activated potassium channel (KCa3.1).
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出处 《免疫学杂志》 CAS CSCD 北大核心 2015年第5期441-445,共5页 Immunological Journal
关键词 T淋巴细胞 K+通道 CRAC通道 CA2+ T lymphocyte K+ channels CRAC Ca2+
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参考文献33

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二级参考文献60

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