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肾移植术后抗磷脂酶A2受体抗体阳性的复发性膜性肾病 被引量：5

Recurrent membranous nephropathy with phospholipase A2 receptor antibody
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摘要 40岁男性患者,既往临床表现肾病综合征,自体肾活检诊断膜性肾病(MN),抗磷脂酶A2受体(PLA2R)抗体滴度阳性,起病后7年进入慢性肾衰竭行血液透析(HD)治疗,HD治疗5个月后接受亲属活体肾移植,术前抗PLA2R抗体阳性。移植术后6个月尿蛋白阳性,抗PLA2R抗体滴度升高,移植肾活检提示MN复发。以抗CD20单克隆抗体(美罗华)375 mg/m^2治疗后,患者蛋白尿转阴,抗PLA2R抗体滴度下降。 A middle-aged male was admitted for nephritic syndrome, and diagnosed membranous nephropathy （MN） by renal biopsy of native kidney as well as phospholipase A2 receptor （PLA2R） antibody positive. There was no secondary available factor. Graft biopsy-proven recurrent MN developed at 5 months post-transplant. The levels of proteiniura and serum PLA2R antibody were decreased after the treatment of rituximab.
作者 程东瑞 倪雪峰 陈惠萍
机构地区 南京军区南京总医院肾脏科
出处 《肾脏病与透析肾移植杂志》 CAS CSCD 北大核心 2015年第2期195-199,共5页 Chinese Journal of Nephrology,Dialysis & Transplantation
关键词 肾移植 膜性肾病复发 抗磷脂酶A2受体抗体 利妥昔单抗 post renal transplantation proteinuria phospholipase A2 receptor antibodies rituximab
分类号 R699.2 [医药卫生—泌尿科学]
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参考文献21

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同被引文献29

引证文献5

二级引证文献11

肾脏病与透析肾移植杂志
2015年 第2期

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