摘要
链霉菌是革兰氏阳性丝状细菌,其次级代谢产物具有抗感染、抗虫、抗肿瘤、免疫调节等生理活性,在医药、食品和农业领域具有重要应用价值。链霉菌的遗传操作技术是发现和改良新次级代谢产物的基础,近年来合成生物学的兴起为链霉菌的研发提供了全新的视角。综述了合成生物学在链霉菌次级产物生物合成基因簇克隆与组装、底盘细胞设计与改造、调节两者适配性方面的应用进展。
Streptomyces, a kind of Gram-positive bacteria, can produce lots of secondary metabolites which are widely used in the pharmaceutical industry, food processing and agriculture production. Genetic manipulation for Streptomyces is the foundation for the discovery and development of new secondary metabolites. The emergence of synthetic biology opens a new window for researches in Streptomyces and achievements on cloning and assembly of the biosynthetic gene cluster, the chassis cell design and the fitness were reviewed.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2015年第4期92-97,共6页
China Biotechnology
基金
国家自然科学基金资助项目(31370092)
