甲状腺显示胸腺样分化癌临床病理观察

Thyroid carcinoma showing thymus- like differentiation: a clinicopathologic study

目的探讨甲状腺显示胸腺样分化癌(CASTLE)的临床病理特征。方法对2例CASTLE进行组织形态学观察及免疫组化检测,并复习相关文献。结果 2例CASTLE均位于甲状腺下极,肿瘤呈推进式生长,肿瘤细胞梭形或多边形,排列成巢状或岛状,有纤维间隔,多形性不明显,核分裂少见。免疫组化:CD5、CD117和CEA(+)。结论 CASTLE是一种少见的甲状腺低度恶性肿瘤,有独特的组织学结构及免疫组化特点。

Objective To study the clinicopathologic features of thyroid carcinoma showing thymus-like differentiation （CASTLE）. Methods Pathologic features of 2 cases of CASTLE were analyzed, immunohistochemical study was performed, with review of literature. Results Two cases were located in the lower pole, with an expansive growth pattern, the tumors consisted of islands or nests of epithelial cells separated by thick fibrous septa, with rare or infrequent mitoses. Immunohistochemically, the tumor cells were consistently positive for CEA, CD5 and CD117. Conclusions CASTLE is a low-grade thyroid carcinoma with the typically morphologic features and immunophenotypes.