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帕金森病大鼠模型运动行为测评方法的研究进展 被引量：11

Progress of behavioral tests in rat models of Parkinson's disease
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摘要 帕金森病(Parkinson’s disease,PD)是以静止性震颤、肌强直、动作迟缓、姿势平衡障碍为主要临床特征的神经退行性疾病。动物模型实验是PD研究的重要组成方面,针对PD动物模型运动行为的评价不仅有利于阐述PD的发病原因及发病机制,而且有利于判定新型治疗方法的疗效。本文以偏侧6-OHDA大鼠模型为研究对象,着重介绍非药物诱导行为学测试方法对PD大鼠运动功能障碍进行测试与评价的研究进展。 Parkinson’ s disease （ PD） is a neurodegenerative disorder primarily characterized by resting tremor, muscular rigidity, akinesia and postural reflex impairment.Behavioral tests of PD in animal models are essential for under-standing the pathogenesis of PD as well as for the development and testing of potential therapeutics .Here we mainly use the 6-hydroxydopamine （6-OHDA）-induced rat model, to introduce a review on the research progress in non-drug-induced be-havioral tests of motor function in PD rats.
作者 魏翔 刘晓莉
机构地区 北京师范大学体育与运动学院
出处 《中国实验动物学报》 CAS CSCD 北大核心 2015年第2期209-215,共7页 Acta Laboratorium Animalis Scientia Sinica
基金 国家自然科学基金资助项目(项目编号:31340025)
关键词 帕金森病 大鼠 运动功能 行为学测试 Parkinson’ s disease Rat Motor function Behavioral tests
分类号 Q95-33 [生物学—动物学]
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参考文献62

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二级参考文献23

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共引文献9

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二级引证文献31

中国实验动物学报
2015年 第2期

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