改良腹腔镜胃镜双镜联合手术治疗固有肌层来源胃间质瘤

Modified laparoscopic combined with gastroscopic surgery for the gastric stromal tumors from the muscularis propria

目的 探讨改良腹腔镜胃镜双镜联合手术治疗固有肌层来源胃间质瘤的临床疗效.方法 回顾性分析2011年1月至2014年1月山东大学附属千佛山医院收治的25例固有肌层来源的胃间质瘤患者的临床资料.患者采用气管插管全身麻醉;脐上缘做一0.5 cm的弧形切口,建立气腹,置入腹腔镜观察;再行胃镜检查并定位肿瘤;腹腔镜经脐置入腹腔,另2个穿刺套管经胃前壁刺入胃腔;腹腔镜器械在胃腔内切除肿瘤;胃镜下经口取出肿瘤,钛夹夹闭创面及胃壁上穿刺孔.患者术后置入鼻胃管,进行胃肠减压,常规应用质子泵抑制剂及抗生素治疗3d;对于病理学检查证实为中危及高危的胃间质瘤患者,在肿瘤完整切除后,应用伊马替尼辅助治疗.其余胃间质瘤患者,手术完整切除后,不行任何辅助治疗.术后1年内每3个月复查1次胃镜,1年后每6个月复查1次胃镜.术后1年内每6个月复查1次腹部CT,1年后每年复查1次腹部CT.随访时间截至2014年12月.结果 25例患者顺利完成改良腹腔镜胃镜双镜联合手术,无中转开腹.患者手术时间为（79±4） min,术中出血量为（28 ±3）mL,肿瘤直径为（2.6±0.3）cm,术后腹痛时间为（2.8±0.3）d,住院时间为（6.3±0.3）d.25例患者均未出现并发症.术后病理学检查结果证实切除的肿瘤均为胃间质瘤,核分裂象数为（3.3±0.3）个/50个高倍视野,达到R0切除.其中极低危3例,低危19例,中危3例,高危0例.3例中危胃间质瘤患者中,2例遵医嘱服药,服药期间未出现药物不良反应;另外1例由于经济原因,拒服药物治疗.25例患者随访12∽36个月,均未见肿瘤复发及转移.结论 改良腹腔镜胃镜双镜联合手术治疗固有肌层来源的胃间质瘤安全、有效.

Objective To explore the clinical effects of laparoscopic combined with gastroscopic surgery for the gastric stromal tumors （GSTs） from the muscularis propria.Methods The clinical data of 25 patients with GSTs from the muscularis propria who were admitted to the Qianfoshan Hospital Affiliated to Shandong University between January 2011 and January 2014 were retrospectively analyzed.Patients received the general anaesthesia by endotracheal intubation.The pneumoperitoneum was done by an arc incision of 0.5 cm above margin of the umbilical cord and then laparoscopy was placed for exposing and gastroscopy was placed for confirming the location of the tumor.A laparoscope was placed in the cavity via the trocar at the navel,and the other two trocars penetrated both the abdominal and stomach walls.With gastroscopic monitoring,the operation was carried out in the gastric lumen using laparoscopic instruments and the tumor was resected.The tumor tissue was removed orally using a gastroscopic basket,and puncture holes and perforations were sutured using titanium clips.The proton pump inhibitor and antibiotics were used as the conventional therapy for 3 days,while adjuvant therapy with a usage of imatinib was applied to patients who were confirmed with the high-risk GSTs by pathological examination after tumors resection,and the other patients did not receive adjuvant therapy.Gastroscopic reexamination was done every 3 months within postoperative 1 year and then every 6 months after 1 year.Abdominal CT reexamination was done every 6 months within postoperative 1 year and then every 1 year after 1 year.The followup was done till December 2014.Results All the 25 patients received successfully modified laparoscopic combined with gastroscopic surgery without conversion to open surgery and postoperative complication.The operation time,volume of intraoperative blood loss,diameter of tumor,duration of postoperative abdominal pain and duration of hospital stay were （79 ± 4） minutes,（28 ± 3） mL,（2.6 ± 0.3） cm,（2.8 ± 0.3） days and （6.3 ± 0.3） days,respectively.GSTs were confirmed by postoperative pathological examination.The mitotic count was （3.3 ± 0.3） /50 HPF and reached R0 resection.Extremely low risk was detected in 3 patients,low risk in 19 patients,intermediate risk in 3 patients and no high risk was detected.Two of 3 patients with intermediate risk took the medicines following instructions without the adverse drug reaction,and 1 of 3 patients refused to take the medicines due to low income.All the patients were followed up for 12-36 months without the recurrence or metastasis of tumors.Conclusion Modified laparoscopic combined with gastroscopic surgery is feasible and effective for the treatment of gastric stromal tumors （GSTs） from the muscularis propria.