血清SCC和CRP联合检测的临床意义

Clinical significance of combined detection of SCC and CRP levels

目的分析血清SCC和CRP联合检测在区分上呼吸道感染和肺部鳞状上皮细胞癌患者中的作用,探讨其临床意义。方法取89例上呼吸道感染患者和38例肺部鳞状上皮细胞癌患者血清。采用i2000全自动免疫分析仪测定SCC,P800全自动生化分析仪测定CRP,分析抗炎症治疗前后上呼吸道感染患者和肺部鳞状上皮细胞癌患者SCC水平的变化与炎症指标CRP水平变化的关系。结果经抗炎治疗后,上呼吸道感染患者CRP水平从(54.972±76.340)mg/L降低至(24.388±41.333)mg/L,SCC水平从(8.181±8.452)mg/L降低至(1.611±1.641)mg/L;经抗炎治疗后,肺部鳞状上皮细胞癌患者CRP水平从(55.24±59.409)mg/L降低至(26.24±32.334)mg/L,SCC水平则无明显变化;治疗后上呼吸道感染患者SCC水平显著低于肺部鳞状上皮细胞癌患者。结论上呼吸道感染患者治疗后SCC水平显著下降,表明上呼吸道感染患者SCC水平异常与炎症相关。经抗炎治疗后SCC是否由异常升高降低为正常可能是鉴别上呼吸道感染患者与肺部鳞状上皮细胞癌的有效方法 。

Objective To analyze the role of combined detection of squamous cell carcinoma antigen （SCC） and C - reaction protein（CRP） in distinguishing between patients with lung squamous cell carcinoma and the respiratory tract infection, and to explore its clinical significance. Methods Serum samples were collected from 89 patients with respiratory tract infection and 38 patients with lung squamous cell carcinoma. 12000 automatic immune analyzer was employed to detect the level of SCC. P800 automatic biochemical analyzer was used to analyze the level of CRP. The changes of SCC levels from patients with respiratory tract infection and lung squamous cell carcinoma before and after anti - inflammatory treating were compared with changes of in- flammatory biomarkers CRP levels. Results After anti - inflammatory treating, the CRP level of patients with respiratory tract infection was reduced from （54. 972±76. 340） mg/L to （ 24. 388 ± 41. 333 ） rag/L, and the SCC level was reduced from （ 8. 181 ± 8. 452） mg/L to （ 1. 611 ± 1. 641 ） mg,/L. The CRP level of patients with lung squamous cell cancer was reduced form （55.24±59.409） mg/L to （26.24±32. 334） mg/L, the level of SCC had no obvious change. The level of patients with respiratory tract infection was significantly lower than that of patients with lung squamous cell cancer. Conclusion SCC level decreased significantly after treatment in patients with respiratory tract infection indicates that the abnormality of SCC level is re- lated to inflammation in patients with respiratory tract infection. Observation of whether SCC level decreasing from an abnormal level to a normal level maybe an effective way to distinguish between patients with lung squamous cell carcinoma and the respira- tory tract infection.