健康成年人半乳糖凝集素-3参考范围调查

Galectin-3 reference range survey of healthy adults

目的调查健康人群血清半乳糖凝集素-3参考范围。方法用ELISA法检测1 173名（男585名,女588名）健康成年人半乳糖凝集素-3水平。结果半乳糖凝集素-3参考范围：男性（21～30）岁：（3.90±1.86）μg/L;（31～40）岁：（4.33±1.95）μg/L;（41±50）岁：（4.68±1.89）μg/L;（51～70）岁：（5.05±2.21）μg/L;（71～80）岁：（5.23±2.46）μg/L。女性（21～30）岁：（3.51±1.71）μg/L;（31～40）岁：（4.01±1.86）μg/L;（41～50）岁：（4.34±1.89）μg/L;（51～70）岁：（4.73±2.01）μg/L;（71～80）岁：（4.96±2.35）g/L。男女间差异有统计学意义（P〈0.05）。男、女性血清半乳糖凝集素-3水平均随年龄增长呈现升高的趋势。结论健康成年人群血清半乳糖凝集素-3参考范围存在性别、年龄的差异,建议各实验室根据性别、年龄建立各自的参考范围。

Objective To investigate the serum galectin - 3 reference range of healthy adults. Methods The galectin - 3 lev- el of 1 173 （male 585, female 588 ） healthy adults were detected by ELISA. Results Galectin - 3 reference range was （3.90 ± 1.86）μg/L for men （21 -30 years old）, （4.33 ± 1.95） μg/L for men （31 -40 years old）, （4.68± 1.89） μg/L for men （41 -50 years old）, （5.05 ±2.21）μg/L for men （51 -70 years old） and （5.23 ±2.46） μg/L for men （71 - 80 years old）. Galectin - 3 reference range was （3.51 ± 1.71 ）μg/L for women （21 - 30 years old）, （4.01 ± 1.86） μg/L for women （31 -40 years old）, （4.34 ± 1.89） μg/L for women （41 -50 years old）, （4.73 ± 2.01 ） μg/L for women （51 - 70 years old）, and （4.96 ± 2.35） μg/L for women （71 -80 years old）. There were significant differences between men and women （P 〈 0.05 ）. Male and female serum levels of galectin - 3 showed increasing trend with increasing age. Conclu- sion Healthy adult population serum galectin - 3 reference ranges gender, age difference, recommended that the laboratory ac- cording to gender, age build their own reference range.