妊娠期高血压疾病孕妇尿液中激肽原1含量的变化

Change of urinary kininogen-1 content in pregnant women with hypertensive disorder complicating pregnancy

目的:探讨尿液中激肽原1(KNG1)在评估妊娠期高血压疾病严重程度中的临床意义。方法:选取妊娠期高血压、轻度子痫前期、重度子痫前期孕妇及正常健康足月妊娠女性各20例,分别检测其尿液中的KNG1浓度,并与平均动脉压和24 h尿蛋白进行相关性分析。结果:轻度子痫前期组孕妇尿液中KNG1浓度和正常妊娠组比较,差异无统计学意义(P>0.05);而妊娠期高血压组和重度子痫前期组孕妇尿液中KNG1浓度相对于正常妊娠组显著下降,差异有统计学意义(P<0.05),且重度子痫前期组孕妇尿液中KNG1浓度显著低于轻度子痫前期组(P<0.05)。Pearson相关分析显示:尿液中KNG1浓度与平均动脉压呈显著负相关(r=-0.351,P=0.001),但与24 h尿蛋白无相关性(r=-0.136,P=0.301)。结论:尿液中KNG1含量可以作为一项灵敏和可靠指标来评估妊娠期高血压疾病的病情,且在一定程度上反映疾病的严重程度。

Objective： To explore the clinical significance of urinary kininogen- 1 （ KNG1 ） in evaluating the severity of hyperten- sive disorder complicating pregnancy （HDCP） . Methods： Twenty pregnant women with HDCP, twenty pregnant women with mild pre- eclampsia, twenty pregnant women with severe preeclampsia, and twenty healthy full-term pregnant women were selected, KNG1 concentra- tions were detected respectively, then the correlation with mean arterial pressure and 24-hour urinary protein was analyzed. Results： There was no statistically significant difference in urinary KNG1 concentration between mild preeclampsia group and normal pregnancy group （P〉 0. 05） ; urinary KNG1 concentrations in HDCP group and severe preeclampsia group were statistically significantly lower than that in normal pregnancy group （ P〈0. 05 ）, urinary KNG1 concentration in severe preeclampsia group was statistically significantly lower than that in mild preeclampsia group （P〈0.05） . Pearson correlation analysis showed that urinary KNG1 concentration was significantly negatively correlated with mean arterial pressure （ r= -0. 351, P=0. 001 ）, but there was no correlation between urinary KNG1 concentration and 24-hour urinary protein （r=-0. 136, P=0. 301 ） . Conclusion： Urinary KNG1 content can be used as a sensitive and reliable index to evaluate HDCP, and it can reflect severity of the disease to a certain degree.