7-O-[ω-(N-L-氨基酸甲酯)-烷基]-染料木素的合成与表征

Synthesis and Characterization of 7-O-[ω-( N-L-Amino Acid Methyl Ester)-Alkyl]-Genistein

染料木素具有多种生理活性,以染料木素和L-氨基酸为原料,经过染料木素烷基化、氨基酸酯化、偶联3步反应,合成了一系列新的标题化合物,并对8个标题化合物进行了1HNMR、HRMS和IR结构表征。

Genistein has many biological activities,a series of novel 7-O-[ω-（ N-L-amino acid methyl ester）-alkyl]-genisteinderived from genistein and L-amino acid was synthesized via three-step reaction of the genistein alkylation,the amino acid esterification and the coupling reaction. The eight target compounds were confirmed by1 HNMR,HRMS and IR.