中成药通心络对兔腹主动脉及骼动脉球囊损伤后血栓的影响

Effect of traditional Chinese medicine Tongxinluo on rabbit abdominal aorta and iliacartery after balloon injury thrombosis

目的探讨中成药通心络对兔腹主动脉及骼动脉球囊损伤后血栓的影响。方法随机选取90只健康新西兰兔分为三组，模拟损伤后分别给予三组兔予通心络、阿司匹林和安慰剂治疗，取受损节段血管，经HE染色后放置在显微镜下对内膜增生及管腔内血栓形成情况进行观察。结果三组兔子在球囊损伤后1、7d观察可发现髂动脉内膜增生及血管腹主动脉，管腔狭窄程度为5％～40％；模拟损伤后1个月，安慰剂组兔子腹主动脉髂及动脉内膜增生与阿司匹林组及痛心络组比较更加显著（P〈0．05）；通心络膜增生的血管比例及血栓形成血管比例均明显少于其他两组（P〈0．05）。结论兔腹主动脉及骼动脉球囊损伤可作为理想的研究模型，在再狭窄防治中使用通心络治疗能够有效预防血栓发生，可进一步作为有效方案进行研究。

Objective To investigate the effects of Chinese medicine Tongxinluo on thrombosis after abdominal aorta and iliac artery injury. Methods Randomly selected 90 healthy New Zealand rabbits, which were divided into three groups, the three groups of rabbits were given Tongxinluo, aspirin, placebo after simulated injuries, taking the damaged sections of blood vessels, sifter HE staining of endometrial placed under the microscope hyperplasia and thrombosis were observed within the lumen. Results The three groups of rabbits balloon injury 1, 7 d after the observation can be found in the iliac artery and vascular aortic intimal hyperplasia, stenosis in 5% -40% ; Simulate injuries a month later, the rabbit abdominal aorta and iliac artery intimal hyperplasia in placebo group was more significant than that in aspirin group and control group（P 〈0. 05）; Tongxinluo film proportion of angiogenesis and vascular thrombosis was significantly less than the proportion of the other two groups（P 〈0.05）. Conclusions The abdominal aorta and iliac artery balloon injury can be used as an ideal research model in the prevention and treatment of restenosis. Tongxinluo can effectively prevent the occurrence of thrombosis, and can be further studied.