间苯三酚与安定用于处理活跃期停滞的疗效比较

Efficacy of phloroglucinol and diazepam on protracted active phase

目的比较间苯三酚和安定用于处理活跃期停滞的有效性及安全性。方法选取2013年10月至2014年4月南县中医院103例活跃期停滞产妇为研究对象，并随机分为两组：间苯三酚组静脉注射间苯三酚80mg＋氯化钠注射液10ml；安定组静脉注射安定10mg＋氯化钠注射液10ml，观察两组产妇活跃期时间、第二产程时间、分娩结局、分娩期并发症、新生儿Apgar评分、羊水性状等。结果间苯三酚组52例活跃期时间为（191．32±22．86）min，剖宫产率为13．46％；安定组51例活跃期时间为（234．1±24．19）min，剖宫产率为21．57％，两组活跃期时间、剖宫产率比较差异有统计学意义（P〈0．05）。安定组新生儿窒息发生率高于间苯三酚组，差异有统计学意义（P〈0．05），两组羊水性状、第二产程时间、产后2h出血量比较差异未见统计学意义（P〉0．05）。结论间苯三酚用于活跃期停滞时疗效明显，能促进产程进展，提高阴道分娩率，减少剖宫产率，对母婴无不良影响少，值得产科医生推广。

Objective To compare the effect and safety of phloroglucinol and diazepam on protracted active phase. Methods From October 2013 to April 2014, 103 puerperae with protracted active phase treated in Nanxian hospital of traditional Chinese medicine were randomly divided into two groups： phloroglucinol group （ phloroglucinol 80 mg ＋ NS 10 ml, iv） and diazepam group （ diazepam 10 mg＋ NS 10 ml, iv）. The duration of active phase, duration of the second stage of labor, delivery outcome, delivery complications, neonatal Apgar score and the condition of amniotic fluid were observed. Results The average durations of active phase in phloroglucinol group and diazepam group were （191.32±22.86） min and （234.1±24. 19） min, while the cesarean section rates were 13.46% and 21.57%, and the differences were statistically significant （P 〈 0.05）. The neonatal asphyxia rate was higher in diazepam group than that in phloroglucinol group, there was significant difference （P 〈 0.05 ）. There was no significant difference in the character of amniotic fluid, the duration of the second stage of labor or volume of bleeding during two hours after labor. Conclusions Phloroglucinol has significant effect on protracted active phase. It can promote the progress of labor, so as to increase the vaginal delivery rate and decrease cesarean section rate, and has no harmful effect on maternal and infants, so is worthy popularizing by the obstetrician.