重组人脑利钠肽治疗心力衰竭的疗效

Clinical effectiveness analysis of rhBNP for the treatment of patients with heart failure

目的观察重组人脑利钠肽（rhBNP）治疗心力衰竭患者的临床效果。方法选取2009年7月至2013年8月文水县人民医院收治的心力衰竭患者28例，随机分为观察组与对照组，均给予心力衰竭常用方法治疗，如给予利尿剂、血管扩张剂等，对照组加用硝普钠，观察组加用rhBNP，治疗后评价疗效。结果两组治疗后左室射血分数及左室舒张末期内径均有所改善，观察组优于对照组（P〈0．05）。观察组液体入量及差值分别为（745．6±78．4）ml、（325．9±54．3）ml，对照组分别为（739．4±77．9）ml、（147．3±51．3）ml，观察组大于对照组（P〈0．05）。观察组治疗总有效率为92．8％，显著高于对照组的（57．1％，P〈0．05）。结论rhBNP治疗心力衰竭患者临床效果满意，可有效改善患者心功能，建议在临床治疗中推广应用。

Objective To analyze the clinical effectiveness of the rhBNP on patients with heart failure. Methods Twenty-eight patients with heart failure in people＇ s hospital of Wenshui from July 2009 to August 2013 were collected and divided into treatment group and control group, which all received the treatments of diuretics, vasodilators. And the control group and treatment group received nitroprusside and rhBNP respectively on the basis of conventional therapies. Results The levels of LVDD and LVEF of the two groups were both improved after treatment, and the improvement of treatment group were significantly higher than these of control group （ P 〈 0.05 ）. And the difference of fluid intake and output between 24 h and the total efficiency of treatment group were significantly higher than those of control group（P 〈 0.05）. Conclusions The treatment of rhBNP is effective on the patients with heart failure, it can improve the heart function, and is worthy to be popularized in clinics.