45例老年患者药物性肝损伤临床特点分析

Retrospective Analysis of 45 Patients with Drug Induced Liver Injury in the Elderly

目的:探讨老年患者药物性肝损伤病历特点及发病因素,为临床防治提供资料。方法:回顾性分析我院45例老年药物性肝损伤患者服药史、临床表现、基础疾病、治疗及转归等。结果:45例中女32例,男13例;基础疾病主要为心血管病(26%)、骨关节病(14%)、感染性疾病(12%)、感冒(10%)、皮肤病(6%)等;涉及药品64种,其中前5位是中药(56.2%)、解热镇痛药(9.4%)、心血管类药(9.4%)、抗感染药(7.8%)、消化系统药(6.3%);主要临床表现为尿黄、乏力、纳差等;45例患者治愈34例,好转11例。结论:引起老年人药物性肝损伤的药物以中药为主,临床表现形式多样,但转归较好。

Objective： To investigate the characteristics and risk etiological factors of drug-induced liver injury（ DILI） cases in the elderly,and provide information for clinical prevention and treatment. Methods： The clinical data of 45 elderly with DILI were retrospectively analyzed according to their history of medicine,clinical manifestations,underlying diseases,treatment and prognosis. Results： 32 cases of 45 patients were female,male,13 cases. The primary underlying diseases of these patients were cardiovascular disease,osteoarthrosis,infectious diseases,cold,skin diseases and so on.These 45 cases involved 64 drugs,the top 5 were traditional Chinese medicine,anti-inflammatory drugs,cardiovascular drugs,the anti-infective drugs and digestive systems drugs. The main clinical manifestations included urine,fatigue,anorexia. 34 patients were cured,11 patients improved. Conclusion： DILI is dominated by traditional Chinese medicine in the elderly,with various clinical manifestations and favorable prognosis.