乌鸡白凤丸抗炎、镇痛及抗应激的药效学研究

Study on the anti-inflammatory,analgesic and anti-stress effect of Wujibaifeng Pills

目的探讨乌鸡白凤丸抗炎、镇痛及抗应激作用,为其临床应用提供科学的理论依据。方法采用二甲苯致小鼠耳廓肿胀实验、蛋清致大鼠足趾肿胀实验以及大鼠棉球肉芽肿实验,观察乌鸡白凤丸的抗炎作用;应用小鼠热板法、醋酸扭体法观察该药的镇痛作用;通过小鼠耐疲劳、耐缺氧、耐寒冷实验观察该药的抗应激作用。结果抗炎方面:乌鸡白凤丸可显著抑制二甲苯所致小鼠耳廓肿胀度及大鼠致炎后足肿胀度,降低大鼠肉芽肿系数;镇痛方面:乌鸡白凤丸可提高热板法引起的小鼠痛阈值,抑制醋酸所致小鼠扭体反应;抗应激方面:乌鸡白凤丸能增加小鼠负荷游泳时间,延长小鼠常压耐缺氧的存活时间,降低小鼠在低温环境中的死亡率。结论乌鸡白凤丸具有显著的抗炎、镇痛及抗应激作用。

Objective To investigate the anti‐inflammatory ,analgesic and anti‐stress effects of Wujibaifeng Pills .Methods The anti‐inflammatory action of Wujibaifeng Pills was assessed by ear edema induced by using xylene in mice and injected egg white in rats ;the analgesic effect was tested by using the rat body torsion test and hot‐plate test ;antifatigue ,anti‐anoxia and low temperature‐resistant tests were used for evaluating the effects on anti‐stress .Result Anti‐inflammatory aspects ：Wujibaifeng Pills high‐dose can significantly inhibit mouse auricle swelling caused by dimethylbenzene and rats foots swelling ,in addition can also decrease the granuloma of rats .Analgesic aspects ：Wujibaifeng Pills can increase the pain threshold ,inhibit body torsion reaction caused by＆amp;nbsp;acetic acid .Stress resistance aspect ：Wujibaifeng Pills can obviously increase the weight loaded swimming time in mice ,and can pro‐long the survival time of bearing hypoxia at normal pressure in mice and significantly reduce the mortality rate of mice in the low temperature environment in mice .Conclusion Wujibaifeng Pills have significant anti‐inflammatory ,analgesic action and can im‐prove the ability of the body′s resistance to stress .