缩泉胶囊对自然衰老大鼠尿量及尿中离子浓度的影响

Effects of Suoquan Capsules on the urine volume and iron concentration in natural aging rats

目的观察缩泉胶囊对自然衰老大鼠24h尿量、水负荷后5h尿量及尿中Na^＋、K^＋、Cl^-浓度的影响。方法取老年大鼠（20月龄）50只,青年大鼠（3月龄）10只。设置组别为：空白对照组、模型对照组、金匮肾气丸组、缩泉胶囊高、中、低剂量组。用代谢笼法测量大鼠24h尿量及水负荷5h尿量;用生化分析仪测定尿液中Na^＋、K^＋、Cl^-浓度。结果缩泉胶囊中、高剂量组24h尿量明显减少;缩泉胶囊低、中、高剂量组水负荷后5h内尿量明显减少;缩泉胶囊低、中、高剂量组尿液中Na^＋、Cl^-排出量明显减少（P〈0.05-0.01）;缩泉胶囊中、高剂量可以显著增加自然衰老大鼠尿液中K^＋的排出量（P〈0.05）。结论自然衰老大鼠多尿的发生可能与Na^＋、K^＋及Cl^-排泄异常有关,而缩泉胶囊可使＂肾虚多尿＂大鼠尿Na^＋、Cl^-排出减少,尿K^＋排出增加,同时尿量明显减少,表明其抗利尿作用可能是通过保钠排钾的作用实现的。

Objective To study the effects of Suoquan Capsules （SQC） on the 5 h urine volume and Na^＋ ,K^＋ ,Cl^- concentration in natural aging rats .Method 10 young SD rats were chosen as a control and 50 aging SD rats （20 months） were randomly divided into five groups ：model ,Jinkuishenqi Pills group ,SQC with high ,middle and low dose groups .The urine volume at 5 h after the water loaded in rats and at 24 h urine were measured in metabolic cages .The Na^＋ ,K^＋ ,Cl^- concentration in rat urine were meas‐ured by a biochemistry analyzer .Results Compared with the control group ,the 24 h urine volume of SQC with middle and high dose significantly decreased ,while the 5 h urine after the water loaded amount of SQC with low ,middle and high dose group also＆amp;nbsp;significantly decreased .The discharged of Na^＋ ,Cl^- significantly decreased in rats with high ,middle and low dose of SQC after in‐tragastric administration（P〈0 .05‐0 .01） .SQC with high and middle dose significantly increased the discharged amounts of K ＋ in urine of natural aging rats（P〈0 .05） .Conclusion Polyuria in the natural aging rats was possibly related to the excretion of ab‐normal Na^＋ ,K^＋ and Cl^- .SQC can reduce Na^＋ ,Cl^- emission and increase K ＋ excretion in kidney deficiency rats with polyuria and has antidiuretic effect by storing Na^＋ and excreting K ＋ .