含氯法齐明方案治疗耐多药肺结核近期疗效观察

Contain clofazimine solution treatment of multi-drug resistant tuberculosis in the near future curative effect observation

目的:观察和评价含氯法齐明方案治疗耐多药肺结核近期(治疗前6月)效果。方法:选取在我院的耐多药肺结核患者60例,随机分为对照组和治疗组,对照组30例采用6Z、Am、Lfx、X、Y/12Lfx、Z、X、Y治疗方案;治疗组30例采用6Z、Am、Lfx、Cfz、X、Y/12Z、Lfx、Cfz X、Y治疗方案。其中X、Y为根据药敏试验敏感的药物或既往未用过的抗结核药物。结果:治疗组和对照组在治疗第6个月末痰菌阴转率分别为56.7%、30.0%,两组比较具有极显著性差异(P<0.01);治疗组和对照组在治疗第6个月末肺部影像学改变有效例数分别为24例、15例,有效率分别为80%、50%,两组肺部影像学改变有效率相比有极显著性差异(P<0.01)。结论:含氯法齐明方案治疗耐多药肺结核近期疗效显著。

Objective：Observation and evaluation including clofazimine solution treatment of multi‐drug resistant tuberculosis （before 6 month） recent effect .Methods：Selection 60 patients with multidrug‐resistant tuber‐culosis in our hospital ,were randomly divided into control group and treatment group and control group 30 cases , treatment group 30 cases .Treatment control group 6 Am ,Lfx ,X ,Y ,Z ,/12 Lfx ,Z ,X ,Y ;Treatment group：6 Z ,Am ,Lfx ,Cfz ,X ,Y /12 ,Lfx ,Cfz X ,Y ,Z .（X ,Y for sensitive drugs or according to antimicrobial suscepti‐bility test always unused anti‐tb drugs） .Results ：Treatment group and control group in the treatment of the first 6 end phlegm germ feminine changed rate was respectively ：56 .7% ,30 .0% （P 〈 0 .01） statistically significant ;Treatment group and control group in the treatment of the first of June lung imaging change：effective cases of 25 ca‐ses ,13 cases respectively ,effectiveness 80% ,50% respectively（P 〈 0 .01） ,with statistical significance .Conclu‐sion ：Contain clofazimine solution treatment of multi‐drug resistant tuberculosis in the near future curative effect is distinct .