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皮下注射重组人粒细胞集落刺激因子治疗HBV相关慢加急性肝衰竭的安全性研究 被引量：7

Evaluation of the safety of granulocyte colony-stimulating factor subcutaneous injection as treatment for HBV-related acute on chronic liver failure
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摘要 粒细胞集落刺激因子（G-CSF）具有促进粒系母细胞增殖和分化的作用,新近的动物实验证实G-CSF有促进肝细胞再生,改善肝组织病变,提高试验动物存活率的作用.有研究初步证实G-CSF对酒精性因素为主的慢加急性肝衰竭患者具有提高生存率、改善肝脏功能的作用[1].但上述研究未做长期随访,且我国HBV感染为肝衰竭主要诱因,因此对G-CSF治疗HBV相关慢加急性肝衰竭（HBV-ALCF）患者安全性研究具有重要临床意义.本研究采用随机对照方法,对皮下注射G-CSF治疗HBV-ACLF患者的临床资料和随访结果进行分析,以探讨其安全性.
作者 杨昊臻 段学章 刘晓燕 陈靖 童晶晶 荣易辉 肖珑 辛绍杰
机构地区 北京解放军第三○二医院
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2015年第5期378-380,共3页 Chinese Journal of Hepatology
关键词 肝功能衰竭 粒细胞集落刺激因子 安全性 Liver failure Granulocyte colony-stimulating factor Safety
分类号 R512.62 [医药卫生—内科学]
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中华肝脏病杂志
2015年 第5期

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