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BRAF和RAS基因突变在甲状腺乳头状癌不同组织亚型中的表达 被引量：10

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摘要 根据肿瘤有无明确的乳头状结构，甲状腺乳头状癌(PTC)通常被分为经典型和滤泡亚型，而根据肿瘤有无完整的包膜包绕，PTC又被分为浸润性和包裹性，包裹性Frc有完整的纤维包膜包绕，预后比浸润性PTC更好。BRAF、RAS基因的突变与甲状腺癌发生有着密切的联系，BRAFV600E突变在PTC中高表达，与PTC的发生和不良预后关系密切；
作者 王炜
机构地区 杭州市第一人民医院病理科
出处 《中华病理学杂志》 CAS CSCD 北大核心 2015年第5期331-333,共3页 Chinese Journal of Pathology
基金 杭州市卫生科技计划项目(2012B005)
关键词 RAS基因突变 甲状腺乳头状癌 组织亚型 BRAF 纤维包膜 不良预后 乳头状结构 PTC
分类号 R734.340.4 [医药卫生—肿瘤]
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参考文献9

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同被引文献152

  • 1中华医学会内分泌学分会,中华医学会外科学分会内分泌学组,中国抗癌协会头颈肿瘤专业委员会,中华医学会核医学分会.甲状腺结节和分化型甲状腺癌诊治指南[J].中华核医学与分子影像学杂志,2013,33(2):96-115.
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  • 3Takanori Kanazawa,Ken Sugawara,Ko Tanaka,Shogo Horiuchi,Yuuki Takashima,Hiroaki Okada.Suppression of tumor growth by systemic delivery of anti-VEGF siRNA with cell-penetrating peptide-modified MPEG–PCL nanomicelles[J]. European Journal of Pharmaceutics and Biopharmaceutics . 2012 (3)
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  • 5Gao, Congxiao,Maeno, Toshitaka,Ota, Fumi,Ueno, Manabu,Korekane, Hiroaki,Takamatsu, Shinji,Shirato, Ken,Matsumoto, Akio,Kobayashi, Satoshi,Yoshida, Keiichi,Kitazume, Shinobu,Ohtsubo, Kazuaki,Betsuyaku, Tomoko,Taniguchi, Naoyuki.Sensitivity of heterozygous α1,6-fucosyltransferase knock-out mice to cigarette smoke-induced emphysema: Implication of aberrant transforming growth factor-β signaling and matrix metalloproteinase gene expression. Journal of Biological Chemistry . 2012
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引证文献10

二级引证文献53

中华病理学杂志
2015年 第5期

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