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严重脓毒症及脓毒性休克患者抗菌药物PK/PD特点和优化治疗 被引量:3

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摘要 脓毒症是指由感染引起的全身炎症反应综合征,临床上证实有细菌存在或高度可疑感染灶;严重脓毒症是指脓毒症伴有器官功能不良和(或)低灌注、低血压的征象;脓毒性休克是指严重脓毒症给予足量液体复苏后仍伴有无法纠正的持续性低血压,甚至会伴有多器官(1个以上)功能障碍。严重脓毒症及脓毒性休克的发病率和病死率居高不下,北美洲和欧洲每年分别约150万患者发病,死亡率为35%~50%[1]。这类患者病理生理变化较大,使抗菌药物药代动力学(PK)也随之变化,另被感染的致病菌又常为多重耐药菌,因此常规抗菌药物治疗易导致治疗失败。
作者 邸秀珍 王睿
出处 《中华医学杂志》 CAS CSCD 北大核心 2015年第18期1435-1437,共3页 National Medical Journal of China
基金 国家科技部十二五重大专项滚动课题(2012ZX09303004-002)
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