健康中老年人脑血管反应能力分布特征的屏气功能磁共振成像研究

Distribution pattern of cerebrovascular reactivity in healthy middle-aged or elderly people: a breath holding functional magnetic resonance imaging study

目的利用屏气功能磁共振成像(f MRI)评价正常中老年人脑血管反应能力(CVR)的分布特征。方法对25名健康中老年人进行屏气任务的f M RI检测,采用统计参数图8(SPM8)进行数据处理,分析屏气引起的全脑血氧水平依赖(BOLD)信号的变化。分析大脑前动脉、大脑中动脉、大脑后动脉供血的皮层区和基底节区屏气BOLD信号变化的差异。结果屏气引起的BOLD信号升高区域为广泛的皮层灰质和皮层下灰质核团。基底节区的BOLD信号变化百分比(PSC)最低(P<0.001),大脑后动脉供血区的PSC显著高于其他血管区(P<0.05)。结论屏气f MRI是一种可靠的、简便易行的CVR评价方法,正常中老年人基底节区CVR较低,而大脑后动脉供血区的CVR较高。

Objective To assess the distribution pattern of cerebrovascular reactivity （CVR） in healthy middle-aged or elderly people by using breath holding functional magnetic resonance imaging （fMRI）. Methods Twenty-five middle- aged or elderly people were recruited and performed an fMRI with a breath holding task. Statistical parametric mapping 8 （SPM8） was applied in data processing to analyze the blood oxygen level dependent （BOLD） signal chan- ges induced by breath holding. Differences in signal changes during breath holding were detected among the cortical ter- ritory supplied by the anterior cerebral artery, middle cerebral artery, posterior cerebral artery and basal ganglia regions. Results Increased BOLD signal induced by breath holding widely distributed in gray matter cortices and subcortical gray matter nuclei. The lowest percentage of BOLD signal change （PSC） was detected in the basal ganglia regions （ P 〈 0. 001 ）, and the posterior cerebral artery regions showed the highest PSC （ P 〈 0.05 ）. Conclusion Breath hold- ing fMRI is a convenient and reliable method for CVR assessing. Among healthy middle-aged or elderly people, the basal ganglia regions shows the lowest CVR while the PCA territory the highest.