2011~2013年多重耐药鲍曼不动杆菌临床分布及其耐药性分析

Analysis of clinical distribution and drug resistance of multidrug resistant Acinetobacter baumannii 201 1~2013

目的：了解我院2011~2013年临床分离多重耐药鲍曼不动杆菌（Multidrug-resistant A.baumannii,MDRAB）临床分布及其耐药性特征,为临床合理使用抗生素提供可靠依据。方法采用 TDR-200B 系统进行细菌鉴定和药敏试验。运用 WHONET 5.4软件分析试验数据。结果在2011~2013年12月期间,我院共分离126株 MDRAB,该菌临床分离呈逐年快速递增趋势,主要来源于呼吸内科、重症医学科、神经外科、普外科等患有基础疾病并长期使用抗菌药物的老年患者、重大外科手术等危重症患者以及免疫能力低下的患者,以呼吸道感染最常见,对临床常用抗菌药呈高水平耐药。结论我院 MDRAB 检出频率逐年上升,临床分布不均,耐药性严重。

Objective To investigate clinical distribution and drug resistant characteristics of multidrug re-sistant Acinetobacter baumannii （MDRAB）isolated from our hospital 201 1 to 2013 and to provide a reliable ev-idence for clinical further rational use of antibiotics. Methods Bacteria identification and drug sensitivity test were carried out by using the TDR-200B system,and the test data was analyzed by using WHONET5.4 soft-ware. Results A total of 126 strains of MDRAB were isolated from our hospital 201 1 to December 2013.The isolating rate of MDRAB showed a yearly rapid increasing trend.The MDRAB were isolated mainly from elder-ly patients with basic diseases and long-term used antibiotics,patients with critical care who underwent major surgery and patients with subnormal immune ability from department of respiratory medicine,department of intensive care medicine,department of neurosurgery and department of general surgery.Among them,respira-tory tract infection by MDRAB were the most common.The MDRAB from patients with respiratory tract in-fection showed a high resistance to common clinical drugs. Conclusion The detection rate of MDRAB in our hospital increased year by year.Clinical distribution of patients infected with MDRAB was disproportion.Drug resistance of MDRAB is serious.