三种野菜水提液对高脂小鼠血脂代谢的影响

Effects of Water Extract from Scorzonera sinensis Lipsch,Pteridium aquilinum and Sonchus oleraceus L.on Plasma-lipids Metabolism in Mice Fed High Fats Diet

比较桃叶鸦葱、蕨菜、苦菜3种野菜水提液对高血脂小鼠血脂代谢的影响。制备高血脂小鼠模型,采用试剂盒方法测定血浆中血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDLC)和丙二醛(MDA)的水平以及超氧化物歧化酶(SOD)活力。桃叶鸦葱、蕨菜、苦菜3种野菜水提液均能降低高血脂小鼠TC、LDL-C和MDA的水平,提高HDL-C水平和SOD酶活力。与高血脂模型组相比,处理各组有显著差异,并呈现剂量依赖性。桃叶鸦葱、蕨菜、苦菜3种野菜水提液都具有良好的降血脂作用,其机制可能与阻断脂质过氧化有相关,并且桃叶鸦葱水提液降低TG水平,提高HDL-C水平和SOD酶活力的效果优于蕨菜、苦菜水提液,苦菜水提液降低TC的作用优于桃叶鸦葱、蕨菜水提液。

To compare the effects of water extract from Scorzonera sinensis Lipsch , Pteridium aquilinum and Sonchus oleraceus L. on plasma-lipids metabolism in mice fed high fats diet.Experimental hyperlipidemia mice were formed after feeding fatty diet. Plasma total cholesterol （TC）,triglycerides （TG）,high-density lipoprotein cholesterol （HDL-C）,low-density lipoprotein cholesterol （LDL-C） and superoxide dismutase （SOD） activity were assayed.Water extract from Scorzonera sinensis Lipsch, Pteridium aquilinum and Sonchus oleraceus L. could decrease the level of TC,LDL-C and MDA,while increasing HDL-C and SOD activity in mice fed high fats diet.Compared with the hyperlipidemia group,there were significant differences among each treatment group with dose-dependent relationship. Water extract from Scorzonera sinensis Lipsch , Pteridium aquilinum and Sonchus oleraceus L. whose mechanism may relate to block lipid peroxidation all have a better lipid-lowering effect. The effect of water extract from Scorzonera sinensis Lipsch is better than that of water extract from Pteridium aquilinum and Sonchus oleraceus L. on reducing TG,and increasing HDL-C and SOD activity.The effect of water extract from Sonchus oleraceus L. was better than that of water extract from Scorzonera sinensis Lipsch and Pteridium aquilinum on reducing TC.