支气管哮喘-慢性阻塞性肺疾病重叠综合征研究进展

The research progress of asthma and chronic obstructive pulmonary disease overlap syndrome

支气管哮喘(简称哮喘)和慢性阻塞性肺疾病(简称慢阻肺)是两种常见的气流阻塞性疾病,其发病机制和临床特点不同。但临床实践表明,要明确区分哮喘和慢阻肺有时并非易事。针对部分既有哮喘特点又有慢阻肺特点的患者,在2014年全球慢性阻塞性肺疾病防治创议(GOLD)和全球支气管哮喘防治创议(GINA)科学委员会共同提出了一个新名词——哮喘-慢阻肺重叠综合征(ACOS)。至于ACOS是哮喘和慢阻肺两种疾病的并存,还是与同一种疾病的特殊表型,目前尚不清楚。ACOS患者病情重,预后差,临床应引起高度重视,尚须进一步研究。

Asthma and chronic obstructive pulmonary disease（COPD） are common obstructive airway diseases. However, differentiation between these two common diseases remains a daunting challenge despite years of research. For those who concurrently had several features of asthma and COPD, a new term of ＂sthma and COPD Overlap Syndrome （ACOS）＂ was proposed by the Science Committees of the Global Initiative for Chronic Obstructive Lung Disease（GOLD） and the Global Initiative for Asthma （GINA） in 2014, yet authorities were debating whether this overlap syndrome represents the coexistence of two common airway diseases or whether there are common underlying pathogenic mechanisms leading to this common phenotype. Considering that the patients with ACOS might experience critical disease condition and poor prognosis, further researches are needed to investigate the unique population of patients with such lung diseases.