IL-1β基因多态性及幽门螺杆菌感染交互作用与胃癌发生的相关性研究

Correlation between interaction between IL-1 beta gene polymorphism and Helicobacter pylori infection and gastric cancer

目的观察IL-1β基因多态性、幽门螺杆菌(Hp)感染在胃癌患者的分布或表达,探讨两者的交互作用对胃癌发生的影响,以期为胃癌的早期防治提供理论依据。方法选取2009年1月-2014年6月就诊的胃癌患者80例作为胃癌组,同期体检的60名健康者作为对照组,检测IL-1β基因多态性、Hp感染在两组人群中的分布;采用SPSS20.0统计软件进行分析。结果胃癌组中Hp感染的阳性率为73.9%,对照组为36.1%,组间比较差异有统计学意义(P<0.05);基因型C/C在胃癌组与对照组中分别占10.0%和28.3%,C/T在两组中的分别占53.8%和53.3%,T/T在两组中的分布为36.2%和18.4%,3种基因型在两组中的分布差异有统计学意义(P<0.05);3种基因型在胃癌组与对照组中的分布分别为8.8%、51.3%、39.9%与26.7%、56.7%、16.6%,3种基因型在两组中的分布差异有统计学意义(P<0.05)。结论 IL-1B的基因多态性在胃癌患者与健康者中的分布不同,T/T基因型发生胃癌的危险性最高,而C/C基因型发生胃癌的危险性最低,此外Hp感染与IL-lB的基因多态性间的交互作用,共同促进了胃癌的发生。

OBJECTIVE To observe the expression of IL‐1 beta gene polymorphism and distribution of Helicobacter pylori infection in the gastric cancer patients and explore the influence of interaction between the two on the gas‐tric cancer so as to provide theoretical basis for early treatment of gastric cancer .METHODS A total of 80 gastric cancer patients who were treated in the hospital from Jan 2009 to Jun 2014 were assigned as the gastric cancer group ,meanwhile ,60 healthy people who received physical examination were set as the control group .The IL‐1 beta gene polymorphism and distribution of H .pylori infection in the two groups of participants were detected , and the statistical analysis was performed with the use of SPSS20 .0 software .RESULTS The positive rate of H . pylori infection was 73 .9% in the gastric cancer group ,36 .1% in the control group ,with statistical significance between the two groups （P〈0 .05） .As for the distribution of IL‐1B‐31 genotypes ,10 .0% had the C/C genotype in the gastric cancer group ,28 .3% in the control group;53 .8% had the C/T genotype in the gastric cancer group ,53 .3% in the control group;36 .2% had the T/T genotype in the gastric cancer group ,18 .4% in the con‐trol group ,and there was significant difference in the distribution of three genotypes between the two groups （P〈0 .05） .As for the distribution of IL‐1 B‐511 genotypes ,8 .8% had the C/C genotype in the gastric cancer group , 26 .7% in the control group;51 .3% had the C/T genotype in the gastric cancer group ,56 .7% in the control group;39 .9% had the T/T genotype in the gastric cancer group ,16 .6% in the control group ,and there was sig‐nificant difference in the distribution of the three genotypes between the two groups （P〈0 .05） .CONCLUSION The gastric cancer patients differ from the healthy people in the IL‐1 B gene polymorphism ,the patients who carry with the T/T genotype are at the highest risk of gastric cancer ,and the patients who carry with the C/C genotype are the lowest risk of gastric cancer ,in addition ,the interaction between the H .pylori infection and the IL‐1B gene polymorphism stimulates the development of gastric cancer .