多药耐药铜绿假单胞菌与鲍氏不动杆菌耐药特点分析

Drug resistance of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii

目的分析医院铜绿假单胞菌和鲍氏不动杆菌的多药耐药(MDR)特点,为临床选择合适的抗菌药物及联合用药提供参考。方法收集2011年7月-2012年7月华东医院各临床科室送检的铜绿假单胞菌和鲍氏不动杆菌,采用VITEK-2Compact全自动微生物分析系统对分离培养出的细菌进行鉴定和体外药敏分析(MIC),并对其耐药性进行分析。结果收集铜绿假单胞菌和鲍氏不动杆菌共1 299株,其中铜绿假单胞菌890株,鲍氏不动杆菌409株;MDR铜绿假单胞菌对碳青霉烯类药物的耐药性严重,仅次于氟喹诺酮类药物,耐左氧氟沙星的铜绿假单胞菌株对亚胺培南也普遍耐药;鲍氏不动杆菌的MDR率要高于铜绿假单胞菌。结论 MDR铜绿假单胞菌和鲍氏不动杆菌引起的感染日益严重,加强医院感染监测,选择合适的治疗药物,对有效控制两菌引起的感染具有重要意义。

OBJECTIVE To investigate the characteristics of drug resistance of the multidrug‐resistant Pseudomonas aeruginosa and Acinetobacter baumannii isolates so as to provide guidance for reasonable clinical use of antibiotics . METHODSFromJul2011toJul2012,theP.aeruginosaandA.baumanniiisolateswerecollectedfromtheclinical departments of Huadong Hospital ,then the isolated bacteria were identified by using VITEK‐2 Compact automatic microorganism analysis system ,the in vitro drug susceptibility testing was performed to observe the drug resist‐ance .RESULTS A total of 1 299 strains of P .aeruginosa and A .baumannii have been collected ,including 890 strains of P .aeruginosa and 409 strains of A .baumannii .The multidrug‐resistant P .aeruginosa was highly resist‐ant to carbapenems ,and the drug resistance rate to fluoroquinolones was higher ;the levofloxacin‐resistant P . aeruginosa was generally resistant to imipenem ;the drug resistance rate of the multidrug‐resistant A .baumannii was higher than that of the multidrug‐resistant P .aeruginosa .CONCLUSION The infections due to the multidrug‐resistant P .aeruginosa and A .baumannii are increasingly serious .It is of great significance to strengthen the sur‐veillance of nosocomial infections and choose appropriate drugs for treatment so as to effectively control the infec‐tions caused by the two species .