聚维酮碘稀释液预防坏疽性阑尾炎伴穿孔术后感染的效果及安全性研究

Efficacy and safety of povidone-iodine dilutions in prevention of postoperative complicated infections in gangrenous appendicitis patients undergoing perforation

目的探讨聚维酮碘稀释液在预防坏疽性阑尾炎伴穿孔术后感染中的效果及安全性,为临床治疗提供参考。方法选取2012年6月-2014年2月医院收治的93例阑尾炎患者作为研究试验对象,根据入院时间先后将患者分成观察组47例和对照组46例,观察组患者术后采用聚维酮碘进行冲洗,对照组患者常规使用生理盐水冲洗,对比分析两组腹腔及切口感染情况;使用SPSS13.0软件进行统计分析。结果观察组患者术后感染率为2.13%,对照组为13.04%,两组比较差异有统计学意义(P<0.05);观察组患者切口愈合整齐,甲级愈合率为68.08%,对照组患者甲级愈合率为50.00%,两组比较差异有统计学意义(u=2.0859,P<0.05);患者术后体温上升,但体温恢复时间相差不大,两组比较差异无统计学意义,但观察组患者肛门排气时间和住院时间明显低于对照组患者,恢复较好,两组比较差异有统计学意义(P<0.05);两组患者术后均无任何不良反应发生,安全性高,差异无统计学意义。结论聚维酮碘稀释液在预防坏疽性阑尾炎伴穿孔术后腹腔及切口感染中疗效较好,患者术后感染率较低,切口愈合较好,无不良反应发生,安全性高。

OBJECTIVE To explore the efficacy and safety of povidone‐iodine dilutions in prevention of postoperative complicated infections in the gangrenous appendicitis patients undergoing perforation so as to provide guidance for the clinical treatment .METHODS A total of 93 appendicitis patients who were treated in the hospital from Jun 2012 to Feb 2014 were recruited as the study objects and divided into the observation group with 47 cases and the con‐trol group with 46 cases according to the order of admission .The observation group was treated with povidone‐io‐dine for irrigation after the surgery ,while the control group was treated with conventional normal saline for irriga‐tion ;the incidence rates of abdominal and incision infections were observed and compared between the two groups , and the statistical analysis was performed with the use of SPSS13 .0 software .RESULTS The incidence of postoper‐ative infections was 2 .13% in the observation group ,13 .04% in the control group ,and there was significant difference between the two groups （P〈0 .05） .The patients of the observation group had neat incision healing with the grade A incision healing rate of 68 .08% ,significantly higher than 50 .00% of the patients of the control group （u=2 .0859 ,P〈0 .05） .The body temperatures of the patients were elevated after the surgery ,however ,the re‐covery time of the body temperatures did not vary significantly ,the anal exhaust time and length of hospital stay of the observation group were significantly shorter than those of the control group ,with the recovery good（P〈0 .05） .The postoperative adverse reactions occurred in neither of the two groups .CONCLUSION Povidone‐iodine dilutions can achieve significant effect on prevention of postoperative abdominal and incision infections in the gan‐grenous appendicitis patients undergoing perforation ,the incidence of postoperative infections is low ,the incision healing is good ,the adverse reactions do not occur ,and the safety is high in the hospital .