联合检测粪便血红蛋白和转铁蛋白在肠癌疾病防治中的应用

Application of combined detection of fecal hemoglobin and transferrin in prevention and treatment of intestinal cancer disease

目的探讨联合检测粪便血红蛋白和转铁蛋白在社区肠癌疾病防治中的应用价值。方法选择2011年8月至2013年12月在湖北医药学院附属太和医院进行肠癌筛查的大肠癌高危人群120例,其中大肠癌20例,癌前病变40例,大肠息肉60例,都进行粪便血红蛋白和转铁蛋白检测与化学法检测。结果粪便血红蛋白和转铁蛋白检测大肠癌、癌前病变、大肠息肉阳性率分别为100.0%、92.5%和90.0%,化学法检测阳性率分别为100.0%、77.5%和73.3%,结果显示,粪便血红蛋白和转铁蛋白检测大肠息肉与癌前病变阳性率都明显高于化学法,差异有统计学意义(P<0.05)。粪便血红蛋白和转铁蛋白诊断大肠癌和癌前病变的敏感度与特异度都明显高于化学法,差异有统计学意义(P<0.05)。粪便血红蛋白和转铁蛋白诊断大肠癌和癌前病变的阳性似然比和优势比都明显高于化学法,差异有统计学意义(P<0.05)。结论联合检测粪便血红蛋白和转铁蛋白在社区肠癌疾病防治中的应用具有很高的检出率、敏感度与特异度和阳性似然比,适合于肠癌的筛查,值得推广应用。

Objective To investigate the application value of the combined detection of fecal hemoglobin and transferrin in the prevention and treatment of intestinal cancer disease in the community .Methods 120 cases of colo‐rectal cancer high‐risk in our hospital from August 2011 to December 2013 were selected ,including 20 cases of color‐ectal cancer ,40 cases of precancerous lesions and60 cases of colorectal polyps .All cases were performed the detection of fecal hemoglobin and transferrin and the chemical assay was performed .Results The positive rates of fecal hemo‐globin and transferrin detection for colorectal cancer ,precancerous lesions and polyps were 100 .0% ,92 .5% and 90 .0% respectively ,w hich by the chemical assay w ere 100 .0% ,77 .5% and 73 .3% respectively ,the results indicated that positive rates of the detection of fecal hemoglobin and transferring for colorectal polyps and precancerous lesions were significantly higher than those of the chemical method ,the differeces were statistically significant （P〈0 .05） . The sensitivity and specificity of fecal hemoglobin and transferring detection for diagnosing colorectal cancer and pre‐cancerous lesions were significantly higher than those of the chemical method ,the differeces were statistically signifi‐cant （P〈0 .05） .And the likelihood ratio and odds ratios of fecal hemoglobin and transferring detection for diagnosing colorectal cancer and precancerous lesions were also significantly higher than those of the chemical method ,the differ‐ences were statistically significant （P〈0 .05） .Conclusion The application of the combined detection of fecal hemo‐globin and transferrin has very high detection rate ,sensitivity ,specificity and positive likelihood ratio in the preven‐tion and treatment of intestinal cancer disease in the community ,which is suitable for colorectal cancer screening and deserves to be promoted and applied .