接种卡介苗与新生儿病理性黄疸发生及严重程度的相关性

Correlation between BCG vaccination with occurrence and severity of neonatal pathological jaundice

目的探讨接种卡介苗与新生儿病理性黄疸发生及严重程度的相关性。方法选择2011年1月至2013年12月出生的200例新生儿,其中剖宫产85例,顺产115例。剖宫产新生儿分娩后48h接种者40例作为A组,剖宫产新生儿分娩后5d接种者45例作为B组,顺产新生儿分娩后12h接种者50例作为C组,顺产新生儿分娩后3d接种者65例作为D组。观察各组新生儿病理性黄疸发生率与胆红素峰值。结果 (1)C组新生儿病理性黄疸发生率为68.00%,明显高于A、B、D组的35.00%、31.11%、30.76%,差异有统计学意义(χ21=7.256、χ22=7.998、χ23=8.115,P<0.05);(2)C组新生儿血清胆红素峰值为(14.98±4.86)mg/dL,高于A、B、D组的(14.33±3.55)、(13.91±3.08)、(14.02±3.09)mg/dL,差异有统计学意义(t1=6.221、t2=7.018、t3=6.582,P<0.05);(3)A、B、C、D 4组病理性黄疸患儿血清胆红素峰值分别为(14.98±1.76)、(14.61±1.56)、(15.76±2.05)L、(15.76±2.05)mg/dL,比较差异有统计学意义(F=10.223,P<0.05)。结论接种卡介苗时机越早与新生儿病理性黄疸发生率及严重程度越高。

Objective To investigate the correlation between the BCG vaccination with the occurrence and se‐verity of neonatal pathological jaundice .Methods 200 neonates born in our hospital from January 2011 to December 2013 were selected ,including 85 cases of cesarean section and 115 cases of vaginal delivery .40 cases of BCG inocula‐tion at 48 h after cesarean section were classified as the group A ,45 cases of BCG vaccination on 5 d after cesearean section as the group B ,50 cases of BCG vaccination at 12 h after natural birth as the group C and 65cases of BCG vac‐cination on 3 d after birth as the group D .The occurrence rate and bilirubin peak of neonatal pathological jaundice were observed in various groups .Results （1）The occurrence rate of neonatal pathological jaundice in the group C was 68 .00% ,which was significantly higher than 35 .00% ,31 .11% and 30 .76% in the group A ,B and D ,the differ‐ences were statistically significant （χ1^2 =7 .256 ,χ2^2 =7 .998 ,χ3^2 =8 .115 ,P〈0 .05）;（2）The serum bilirubin peak value in the group C was （14 .98 ± 4 .86）mg/dL ,which was higher than （14 .33 ± 3 .55） ,（13 .91 ± 3 .08） ,（14 .02 ± 3 .09） mg/dL in the group A ,B and D ,the differences were statistically significant （t1 =6 .221 ,t2 =7 .018 ,t3 =6 .582 ,P〈0 .05）;（3）The serum bilirubin peak values in neonates with pathologic jaundice of the group A ,B ,C and D were （14 .98 ± 1 .76） ,（14 .61 ± 1 .56） ,（15 .76 ± 2 .05） ,（15 .76 ± 2 .05） mg/dL respectively ,the differences were statisti‐cally significant （F=10 .223 ,P〈0 .05） .Conclusion The earlier of BCG vaccination time ,the higher of incidence and severity of neonatal pathological jaundice .