24例丙戊酸和美罗培南相互作用的回顾性分析

Retrospective analysis of the interaction between valproic acid and meropenem in 24 patients

目的探讨丙戊酸和美罗培南的相互作用以提高用药的合理性和安全性。方法收集本院2011年1月至2014年3月入院的患者中合用美罗培南和丙戊酸的相关数据,回顾性分析探讨丙戊酸和美罗培南相互作用。结果 24例患者合用丙戊酸和美罗培南期间,丙戊酸血药浓度明显下降,下降幅度在66.86%~96.47%。结论丙戊酸和美罗培南合用短时间内血浆丙戊酸浓度显著降低,临床上应尽量避免两者合用。

Objective To discuss the drug interaction between valproic acid （VPA） and meropenem and to improve the safety and rationality of drug use. Methods Data of inpatients who were co-administered VPA and meropenem were collected in our hospital, to retrospectively analyze the interaction between VPA and meropenem. Results In 24 patients with combined use of VPA and meropenem, the plasma concentration of VPA was decreased significantly （66.86% - 96.47%）. Conclusion Concomitant administration of VPA and meropenem leads to a rapid decline in plasma concentration of VPA. To avoid the recurrence of epileptic seizures, the co-administration of VPA and meropenem should be avoided in clinical practice.