陕西省宫颈腺癌危险因素探讨

Probe into risk factors of cervical adenocarcinoma in Shaanxi province

[目的]探讨陕西省宫颈腺癌发病的相关危险因素,为宫颈腺癌高发的原因研究提供线索。[方法]采用以医院为基础的1︰2配对病例对照研究法,研究对象选自2011年9月—2012年9月陕西省西安市各大医院经病理检查确诊的宫颈腺癌病人35例作为病例组。对照组分两部分,一部分选择同期与病例组同医院体检中心体检人员或病人陪护家属作为一般对照组,且根据病例组病人年龄特征(±2岁)选择对照并进行1︰2配对,共35对;另一部分选择同期与病例组同医院就诊的经病理检查确诊为宫颈鳞癌病人作为宫颈鳞癌对照组,且根据病例组的年龄特征(±2岁)选择对照并进行1︰2配对,共35对。病例组分别与对照组进行比较。采用统一的结构式问卷进行调查。[结果]宫颈腺癌病人与正常人群相比,进入回归方程的变量为家庭人均年收入、饮用水来源、性格类型;宫颈腺癌与宫颈鳞癌病人相比,进入回归方程的变量为被动吸烟、性格类型。[结论]家庭人均年收入和饮用水类型是引发陕西省妇女宫颈腺癌的危险因素;内向型性格是引发宫颈腺癌和宫颈鳞癌共同的危险因素;被动吸烟是宫颈鳞癌的危险因素,但不是宫颈腺癌的危险因素。

Objective：To probe into the related risk factors of pathogenesis of cervical adenocarcinoma in Shaanxi province ,and to provide clues for further research on causes of high incidence of cervical adenocarcinoma .Meth‐ods：A total of 35 cervical adenocarcinoma patients diagnosed by pathological examination were selected as case group from Xi’an all large hospitals in Shaanxi province from 2011 September to 2012 September by using hos‐pital based 1∶2 matched case control study .Patients in control group were divided into two parts ：Part one selected form hospital medical examination center and medical examiners in the same period with the case group or the patient of accompanying family members as ageneral control group .Part two selected form hospitalzed cervical squamous cell carcinoma patients diagnosed by pathological examination in the same period with the case group as control group .The two parts of patients were selected and received 1∶2 paired according to the characteristics of age （＋2 years） of case group patients ,totally of 35 pairs .Patients in case group were com‐pared with that in control group respectively .They were investigated by using a unified structured question‐naire .Results：Compared with the normal population ,variables entered the regression equation in cervical adeno‐carcinoma patients included the average year income ,drinking water source ,type of character .Compared with the cervical squamous cell carcinoma patients ,variables in patients with adenocarcinoma entered the regression equation included passive smoking and personality type .Conclusion：Family per capita year income and the type of drinking water are the risk factors of cervical adenocarcinoma in women in Shaanxi province .Introverted per‐sonality is common risk factor of cervical squamous cell carcinoma and cervical adenocarcinoma .Passive smok‐ing is a risk factor of cervical squamous cell carcinoma ,but not the risk factor of cervical adenocarcinoma .