摘要
胃癌患者的预后与营养不良密切相关，导致胃癌患者营养不良的机制目前并不十分明确，除了厌食、进食困难等，胃癌患者营养不良可能与宿主-肿瘤相互作用产生具有代谢活性的因子如肿瘤坏死因子-α、白细胞介素-1、白细胞介素-6、干扰素、瘦素、核因子-κB等。相关因子之间关系复杂，相互调控，构成一个精密的调控网络。因此，进一步探索胃癌患者营养不良与相关因子之间的关系，可能为改善患者营养状况及预后提供一定的研究基础。
Malnutrition is one of the most important factors for the prognosis of patients with gastric cancer,but the mechanism of malnutrition is unclear at present. These patients are at risk of nutritional deple-tion from anorexia,dysphagia,and may be associated with the presence of two or more of the following cyto-kines with metabolic activity such as TNF-α,IL-1,IL-6,interferon,leptin,nuclear factor-κB and so on, which are secreted by the host-tumor interaction. The cytokines constitute a sophisticated regulatory network. Therefore,the study of the relationship between malnutrition and related factors in patients with gastric cancer may improve the nutritional status and prognosis of these patients.
出处
《国际肿瘤学杂志》
CAS
2015年第3期221-223,共3页
Journal of International Oncology
基金
云南省卫生科技计划项目（2012WS0036）
关键词
胃肿瘤
细胞因子类
营养状况
Stomach neoplasms
Cytokines
Nutritional status
