人乳头状瘤病毒相关头颈部鳞状细胞癌的研究进展

Research advances of human papillomavirus-related head and neck squamous cell carcinoma

近年来，人乳头状瘤病毒（HPV）相关头颈部鳞状细胞癌的发病率呈上升趋势，尤其表现在口腔鳞状细胞癌中。HPV 相关头颈部鳞状细胞癌具有独特的临床特征、生物学特点及良好预后，且不暴露于吸烟、饮酒等危险因素，其生物标记物及治疗是国际的研究热点。

Recently,the prevalence of human papillomavirus（HPV）infection in head and neck squa-mous cancers has shown an upward trend,especially in the oropharynx squamous carcinoma. This subset of head and neck cancers possesses distinct clinical and laboratory features and outcome,and is particulary com-mon in individuals who lack the traditional risk factors of tobacco and alcohol abuse. The biological markers and treatment of HPV associated head neck cancers are hot topic in current international research.