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原癌基因 Bmi-1与非小细胞肺癌 被引量：1

Proto-oncogene Bmi-1 and non-small cell lung cancer
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摘要 B 细胞特异的莫洛尼白血病毒插入位点1（Bmi-1）基因是多梳基因家族的核心成员之一，被认为是一种原癌基因，在细胞的自我更新、增殖及凋亡方面发挥重要作用。研究证实，Bmi-1的高表达与非小细胞肺癌的发生、发展、侵袭及预后密切相关。Bmi-1基因有望成为一种新的肿瘤分子标志物，为非小细胞肺癌的诊断、靶向治疗提供新的方向。 B-cell specific moloney leukemia virus insertion site 1（Bmi-1）gene is a core member of the polycomb group genes,considered to be a proto-oncogene;Bmi-1 plays an important role in cell self-renewal, proliferation and apoptosis. Several studies have shown that Bmi-1 is highly expressed in non-small cell lung cancer;furthermore,the expression level of Bmi-1 is closely related to the occurrence,development,incursion and prognosis of non-small cell lung cancer. Bmi-1 is expected to become a novel tumor molecular marker,and provides a new direction for the treatment of non-small cell lung cancer.
作者 赖祥丽 冯国生
机构地区 广西壮族自治区人民医院化疗科
出处 《国际肿瘤学杂志》 CAS 2015年第4期295-297,共3页 Journal of International Oncology
关键词 原癌基因 癌 非小细胞肺 BMI-1 Proto-oncogene Carcinoma,non-small-cell lung Bmi-1
分类号 R734.2 [医药卫生—肿瘤]
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参考文献23

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二级参考文献75

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国际肿瘤学杂志
2015年 第4期

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