循环肿瘤细胞检测在非小细胞肺癌中的应用

Application of circulating tumor cells detection in non-small cell lung cancer

循环肿瘤细胞（CTC）是非小细胞肺癌（NSCLC）发生复发转移的重要原因。随着检测技术的不断发展，近期研究结果提示，CTC 水平不仅可以用来判断肿瘤临床分期、评估患者预后及治疗反应，还可以用于早期 NSCLC 的风险评估。另外，作为一种非侵入性的“液体活检”，CTC 检测能反映原发肿瘤的分子生物学及遗传学特征，有助于患者获得最佳的个体化治疗。

Circulating tumor cells（CTCs）are essential for establishing metastasis and recurrence in non-small cell lung cancer（NSCLC）. With the development of detection technique,results from recent studies suggest that CTC level could be a supplement for TNM staging system and a prediction marker of prognosis and therapeutic efficacy,and even could be applied for risk assessment of early NSCLC. Furthermore,as a non-invasive＂liquid biopsy＂,detection of CTC can reflect the molecular biology and genetics characteristics of the primary tumor,and subsequently assist in selecting an optimal individualized treatment.