肺炎支原体感染患儿D-二聚体检测与临床意义

D-dimer testing and clinical significance of mycoplasma pneumoniae infected children

目的探讨肺炎支原体感染患儿血浆D-二聚体含量在肺炎支原体感染过程中的变化及临床意义。方法将来自深圳市宝安妇幼保健院2012年7月至2014年3月住院期间的176例肺炎支原体感染患儿依其病程分为感染组(176例)和治愈组(60例),同时选取70例正常儿童作为对照组,分别测定其血浆D-二聚体及血清肺炎支原体抗体,并对其进行比较分析。结果肺炎支原体感染组患儿血浆D-二聚体水平较治愈组和对照组显著升高(t值分别为4.33和5.11,均P<0.05)、肺炎支原体感染期间(肺炎支原体抗体滴度水平在1:320及以上者53例,滴度在1:160者65例,滴度1:80的58例)不同抗体水平的患儿血浆D-二聚体水平均无明显差异(t值分别为0.64、0.48和1.40,均P>0.05)。结论肺炎支原体感染患儿体内存在着凝血、纤溶活性的异常,D-二聚体水平在感染期明显升高。

Objective To investigate the changes in infection period and significance of plasma D-dimer levels in mycoplasma pneumoniae infected children.Methods From July 2012 to March 2014 plasma D-dimer and mycoplasma pneumoniae antibodies in serum of 176 cases of mycoplasma pneumonia in infection group admitted in Maternal and Child Health Care Hospital of Baoan District, cure group （n=60） and control group （ n=70） were measured, and comparison analysis was conducted.Results Mycoplasma pneumoniae infection group has significantly higher level of plasma D-dimer than the cure group and the control group （t value was 4.33 and 5.11, respectively, both P〈0.05）.During the mycoplasma pneumoniae infection period there was no significant difference in D-dimer level among cases with different antibody levels （53 cases with titer of 1：320 or more, 65 cases with titer of 1：160, 58 cases with titer of 1：80） （t value was 0.64, 0.48 and 1.40, respectively, all P 〉0.05）.Conclusion In vivo coagulation and fibrinolytic activity abnormalities exist in children with mycoplasma pneumoniae infection, and their D-dimer levels elevate significantly in infection period.