核因子-κB家族成员c-Rel在自身免疫病发病机制及治疗中的研究进展

Advances of transcription factor c-Rel in the pathogenesis and treatment of autoimmune diseases

哺乳动物核因子-κB （NF-κB）家族由c-Rel、RelA（p65）、RelB、NF-κB1（p50/p105）以及NF-κB2（p52/p100）五名成员组成.相比于其它家族成员广泛表达于机体的各种细胞,c-Rel主要在活化的淋巴细胞和单核细胞中表达,并与多种免疫细胞的分化以及炎性因子的表达密切相关,从而在自身免疫病的病理过程中发挥着重要作用.

The mammalian nuclear factor-kappaB （NF-κB） family consists of five members：c-Rel、RelA（p65） 、RelB,NF-κB1 （p50/p105） and NF-κB2（p52/p100）,each of which is endowed with a distinct set of function not shared by other members,although each member may also perform additional functions common to the family.Unlike other members of the NF-κB family that are ubiquitously expressed,c-Rel is preferentially expressed by inflammatory cells and is used to directly control the expression of multiple inflammatory genes that mediate autoimmune diseases such as autoimmune encephalomyelitis and psoriasis,and its alteration is associated with an increased risk for human inflammatory diseases.Thus c-Rel is not only a pathogenic gene but also a susceptibility gene for autoimmune diseases.