维生素D在儿童呼吸系统疾病中的研究进展

The recent advances of the studies on vitamin D in the children＆#39;s respiratory diseases

维生素D是人体不可缺少的营养素之一,具有广泛的生物学效应.维生素D不仅调节钙磷代谢,促进骨骼钙化,还作为重要的免疫调节因子在固有免疫应答和适应性免疫应答中发挥着重要作用,与呼吸系统疾病发生、发展密切相关.近年研究表明,维生素D缺乏可使免疫细胞增殖和分化偏移而产生异常免疫反应,增加呼吸系统疾病易感性和严重程度.儿童是维生素D缺乏的高危人群,深入研究维生素D的免疫调节功能,将为治疗儿童呼吸系统疾病提供理论基础.

Vitamin D is one of the nutrients which is necessary for human body.It has extensive biological effects.Not only does it regulate calcium and phosphorus metabolism,promote bone calcification,but also works as an important immune regulatory factor that plays an important role in the innate and the adaptive immune response.Vitamin D has a close association with the occurrence and the development of respiratory diseases.Recent researches have shown that vitamin D deficiency can cause abnormal immune reaction due to the shifts of the proliferation and differentiation of immune cells,which may increase the susceptibility and severity of respiratory diseases.Children are in the high-risk group of vitamin D deficiency.Study on the immune regulating function of vitamin D will provide basis for the treatment of children＆#39;s respiratory diseases.