靶向给药体系在骨转移瘤中的研究进展

The advances of targeted drug delivery system in bone metastasis

骨骼是除肝脏和肺脏外恶性肿瘤最常见的转移部位.骨转移（bone metastasis）被认为是临床严重的并发症之一.有文献显示超过70％的各类癌症晚期患者会发生骨转移,骨转移会诱发骨痛、病理性骨折、脊髓压迫和高钙血症等,因其导致的死亡率和致残率分别为20％和45％.在保证治疗原发肿瘤的基础上,怎样最大限度的治疗骨转移瘤和诱发最小的副作用是目前医学界研究的热点.靶向给药体系（targeted drug delivery system）包括双磷酸盐类、四环素类、单克隆抗体、聚乙烯亚胺等,它能有效的抑制骨转移,旨在为治疗骨转移提供更有效的策略.

Bones were the most frequent cancer metastatic sites except liver and lung.Bone metastasis is consider one of the serious complications.Several reports showed that more than 70% end-stage cancer patients might have bone metastasis.Bone metastasis could develop pain,pathological fractures,spinal cord compression and hypercalcenia et al.The mortality and disability rate induced by bone metastasis were 20 and 45%,respectively.How to treat bone metastasis and induce the minimal side effects is hot topic of medical research.Targeted drug delivery system contains bisphosphonates,tetracyclines,monoclonal antibodies and polyethylenimine.It could efficiently control bone metastasis and provide resultful therapeutic strategies for treatment of bone metastasis.