我院131例中药不良反应报告分析

Analysis of 131 Cases Traditional Chinese Medicine Adverse Reactions in Our Hospital

目的:统计中药引起的不良反应(ADR)的发生情况,分析ADR发生的特点,为我院临床合理用药提供参考。方法:采用回顾性方法收集我院2013年1月至2014年10月上报的131例中药引起的ADR报告。探讨不良反应和患者性别、年龄、给药途径、药物品种之间的关系,总结对器官或系统损害的主要临床表现。结果:131例ADR中,女性占62.60%,男性占37.40%;41岁以上的中老年患者ADR发生率较高,共占61.83%;静脉滴注是引发ADR的主要给药途径,占87.02%;临床表现主要是皮肤及其附件损害、全身性损害、胃肠系统损害和呼吸系统损害,分别占43.23%、15.28%、12.66%和11.79%。结论:应重视中药的ADR报告和监测工作,以减少和避免ADR的发生,保障患者用药安全。

Objective： To collect the situation and analyze the features of traditional Chinese medicine adverse reaction, so as to provide reference for clinical rational drug use in our hospital.Methods： 131 cases adverse drug reactions caused by traditional Chinese medicine from January 2013 to October 2014 were collected by retrospective methods, and the relation of adverse drug reactions and patient age, gender, administration route, drugs were discussed and the main clinical manifestations of organ or system damage were summarized.Results：Of 131 cases adverse drug reactions, female accounted for 62.60%, while male was 37.40%. Patients above 41 years old with ADR accounted for 61.83%. Percentage of adverse drug reactions caused by intravenous drip was 87.02%. Main damage of clinical manifestations was skin and its accessories, systemic, gastrointestinal and respiratory system, the percentage was 43.23%, 15.28%, 12.66% and 11.79% respectively.Conclusion：It is urgent to pay attention to the reporting and monitoring of traditional Chinese medicine adverse reaction, which can help to avoid the occurrence of adverse drug reaction, and insure the medication safety.